Reactome: A Curated Pathway Database
All 5 results
Pathways (2) Reactions (1) Proteins (1) Others (1)
Protein: UniProt:Q13253 NOG (Homo sapiens)
Last changed: 2014-11-25 20:54:06

Pathway: Signal Transduction (Homo sapiens)
Signal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such as hormones and growth factors, or reacting to other types of stimuli, such as light. Stimulation of transmembrane receptors leads to their conformational change which propagates the signal to the intracellu
Last changed: 2014-11-21 19:49:01

Pathway: Signaling by BMP (Homo sapiens)
The TGF-beta/BMP (bone morphogenetic protein) pathway incorporates several signalling pathways that share most, but not all, components of a central signal transduction engine. The general signalling scheme is rather simple: upon binding of a ligand, an activated plasma membrane receptor complex is formed, which passes on the signal towards the nucleus through a phosphorylated receptor-activated SMAD (
Last changed: 2014-11-21 14:40:22

Reaction: The ligand trap binds the ligand BMP2, blocking BMP signalling (Homo sapiens)
BMP ligand traps are cystine-knot containing proteins which bind BMPs and antagonise their actions. They are active during organ development and morphogenesis. Different BMP ligand traps show specific spatio-temporal expression during development, and selective activity against specific BMP ligands
Last changed: 2014-11-21 06:36:34

Complex: Ligand Trap:BMP2 [extracellular region] (Homo sapiens)
Ligand Trap:BMP2
Last changed: 2007-09-25 08:39:03