Reactome: A Curated Pathway Database
All 8 results
Pathways (5) Reactions (1) Proteins (1) Others (1)
Protein: UniProt:Q14191 WRN (Homo sapiens)
Last changed: 2015-03-12 12:55:37

Pathway: Metabolism of proteins (Homo sapiens)
Protein metabolism comprises the pathways of translation, post-translational modification and protein folding
Last changed: 2015-03-06 23:15:47

Pathway: SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMO proteins are conjugated to lysine residues of target proteins via an isopeptide bond with the C-terminal glycine of SUMO (reviewed in Zhao 2007, Gareau and Lima 2010, Hannoun et al. 2010, Citro and Chiocca 2013, Yang and Chiang 2013). Proteomic analyses indicate that SUMO is conjugated to hundreds of proteins and most targets of SUMOylation are nuclear (Vertegal et al. 2006, Bruderer et al. 2011,
Last changed: 2015-03-06 23:15:47

Pathway: Post-translational protein modification (Homo sapiens)
After translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the body. These modifications include the internal peptide bond cleavages that activate proenzymes, the attachment of oligosaccharide moieties to membrane-bound and secreted proteins, the attachment of lipid o
Last changed: 2015-03-06 23:15:47

Pathway: SUMOylation of DNA damage response and repair proteins (Homo sapiens)
Several factors that participate in DNA damage response and repair are SUMOylated (reviewed in Dou et al. 2011, Bekker-Jensen and Mailand 2011, Ulrich 2012, Psakhye and Jentsch 2012, Bologna and Ferrari 2013, Flotho and Melchior 2013, Jackson and Durocher 2013). SUMOylation can alter enzymatic activity and protein stability or it can serve to recruit additional factors. For example, SUMOylation of Thym
Last changed: 2015-03-06 23:15:47

Pathway: SUMOylation (Homo sapiens)
Small Ubiquitin-like MOdifiers (SUMOs) are a family of 3 proteins (SUMO1,2,3) that are reversibly conjugated to lysine residues of target proteins via a glycine-lysine isopeptide bond (reviewed in Hay 2013, Hannoun et al. 2010, Gareau and Lima 2010, Wilkinson and Henley 2010, Wang and Dasso 2009). Proteomic methods have yielded estimates of hundreds of target proteins. Targets are mostly located in the
Last changed: 2015-03-06 23:15:47

Reaction: CDKN2A (p14-ARF) SUMOylates WRN with SUMO1 (Homo sapiens)
CDKN2A (p14-ARF) SUMOylates WRN at lysine-356, lysine-496, and lysine-898 with SUMO1 (Woods et al. 2004). SUMOylation of WRN causes it to be released from the nucleolus
Last changed: 2015-03-06 10:40:16

Complex: 3SUMO1:WRN [nucleoplasm] (Homo sapiens)
Last changed: 2013-09-19 04:03:07