Reactome: A Curated Pathway Database
Results 1 to 10 of 58
Pathways (15) Reactions (19) Proteins (1) Others (23)
Protein: UniProt:Q14204 DYNC1H1 (Homo sapiens)
Last changed: 2015-03-10 08:59:22

Pathway: Organelle biogenesis and maintenance (Homo sapiens)
This module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reticulum, Golgi apparatus, vacuoles, nucleus, (auto)phagosome, centriole, lysosome, melanosome, myofibril, nucleolus, peroxisome, cilia (in some cell types), proteasome, ribsome, and transport vesicles
Last changed: 2015-03-06 23:15:47

Pathway: Cell Cycle (Homo sapiens)
Last changed: 2015-03-06 23:15:47

Pathway: Immune System (Homo sapiens)
Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system
Last changed: 2015-03-06 23:15:47

Pathway: Cell Cycle, Mitotic (Homo sapiens)
The replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried out during a discrete temporal period known as the S (synthesis)-phase, and chromosome segregation occurs during a massive reorganization to cellular architecture at mitosis. Two gap-phases separate these ma
Last changed: 2015-03-06 23:15:47

Pathway: MHC class II antigen presentation (Homo sapiens)
Antigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exogenous antigenic peptides to CD4+ T helper cells. CD4+ T cells play a central role in immune protection. On their activation they stimulate differentiation of B cells into antibody-producing B-cell blasts an
Last changed: 2015-03-06 23:15:47

Pathway: Assembly of the primary cilium (Homo sapiens)
The primary cilium is one of two main types of cilia present on the surface of many eukaryotic cells (reviewed in Flieghauf et al, 2007). Unlike the motile cilia, which are generally present in large numbers on epithelial cells and are responsible for sensory function as well as wave-like beating motions, the primary cilium is a non-motile sensory organelle with roles in signaling and development and i
Last changed: 2015-03-06 23:15:47

Pathway: Adaptive Immune System (Homo sapiens)
Adaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with remarkable diversity tailored to recognize aspects of particular pathogens or antigens. During infection, dendritic cells (DC) which act as sentinels in the peripheral tissues recognize and pick up the pat
Last changed: 2015-03-06 23:15:47

Pathway: Mitotic G2-G2/M phases (Homo sapiens)
Last changed: 2015-03-06 23:15:47

Pathway: Anchoring of the basal body to the plasma membrane (Homo sapiens)
The primary cilium is a microtubule-based organelle that is present on differentiated cells of nearly all eukaryotes. Cilium biogenesis is initiated by the docking of basal bodies, a centriole-derived organelle, to the plasma membrane (reviewed in Reiter et al, 2012). The centriole consists of a multiprotein core surrounded by a ring of nine microtubule triplets; the mother centriole additionally has '
Last changed: 2015-03-06 10:40:16

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