Reactome: A Curated Pathway Database
All 7 results
Pathways (4) Reactions (1) Proteins (1) Others (1)
Protein: UniProt:Q14435 GALNT3 (Homo sapiens)
Last changed: 2014-11-26 10:20:21

Pathway: Metabolism of proteins (Homo sapiens)
Protein metabolism comprises the pathways of translation, post-translational modification and protein folding
Last changed: 2014-11-21 19:49:01

Pathway: Post-translational protein modification (Homo sapiens)
After translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the body. These modifications include the internal peptide bond cleavages that activate proenzymes, the attachment of oligosaccharide moieties to membrane-bound and secreted proteins, the attachment of lipid o
Last changed: 2014-11-21 19:49:01

Pathway: O-linked glycosylation (Homo sapiens)
O-glycosylation is an important post-translational modification (PTM) required for correct functioning of many proteins (Van den Steen et al. 1998, Moremen et al. 2012). The O-glycosylation of proteins containing thrombospondin type 1 repeat (TSR) domains and O-glycosylation of mucins are currently described here
Last changed: 2014-11-21 14:40:22

Pathway: O-linked glycosylation of mucins (Homo sapiens)
Mucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most metazoa. Mucins' key characteristic is their ability to form gels; therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell signalling to forming chemical barriers. To date, there are approximately 20 genes that express m
Last changed: 2014-11-21 14:40:22

Reaction: Addition of GalNAc to mucins to form the Tn antigen (Homo sapiens)
The family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases (GalNAc-transferases, GALNTs) carry out the addition of N-acetylgalactosamine on serine or threonine residues of proteins, especially mucins (Wandall et al. 1997). This reaction takes place in the Golgi apparatus (Röttger et al. 1998). There are 20 known members of the GALNT family, 15 of which have been characterised and 5 can
Last changed: 2014-11-21 14:40:22

Complex: GALNT:COSMC [Golgi membrane] (Homo sapiens)
Last changed: 2010-07-21 14:30:22