Reactome: A Curated Pathway Database
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Pathways (7) Reactions (3) Proteins (1) Others (3)
Protein: UniProt:Q14980 NUMA1 (Homo sapiens)
Last changed: 2015-03-10 08:59:22

Pathway: Cell Cycle (Homo sapiens)
Last changed: 2015-03-06 23:15:47

Pathway: Cell Cycle, Mitotic (Homo sapiens)
The replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried out during a discrete temporal period known as the S (synthesis)-phase, and chromosome segregation occurs during a massive reorganization to cellular architecture at mitosis. Two gap-phases separate these ma
Last changed: 2015-03-06 23:15:47

Pathway: Mitotic G2-G2/M phases (Homo sapiens)
Last changed: 2015-03-06 23:15:47

Pathway: Recruitment of mitotic centrosome proteins and complexes (Homo sapiens)
The mitotic spindle becomes established once centrosomes have migrated to opposite poles and the nuclear envelope has broken down. During this stage, interphase centrosomes mature into mitotic centrosomes recruiting additional gamma TuRC complexes and acquiring mitosis-associated centrosomal proteins including NuMA, Plk1 and CDK11p58 (reviewed in Schatten 2008; Raynaud-Messina and Merdes 2007)
Last changed: 2015-03-06 10:40:16

Pathway: Centrosome maturation (Homo sapiens)
The centrosome is the primary microtubule organizing center (MTOC) in vertebrate cells and plays an important role in orchestrating the formation of the mitotic spindle. Centrosome maturation is an early event in this process and involves a major reorganization of centrosomal material at the G2/M transition. During maturation, centrosomes undergo a dramatic increase in size and microtubule nucleating
Last changed: 2015-03-06 10:40:16

Pathway: Recruitment of NuMA to mitotic centrosomes (Homo sapiens)
The NuMA protein, which functions as a nuclear matrix protein in interphase (Merdes and Cleveland 1998), redistributes to the cytoplasm following nuclear envelope breakdown where it plays an essential role in formation and maintenance of the spindle poles (Gaglio, et al., 1995; Gaglio, et al., 1996; Merdes et al, 1996). The mitotic activation of NuMA involves Ran-GTP-dependent dissociation from impo
Last changed: 2015-03-06 10:40:16

Pathway: G2/M Transition (Homo sapiens)
Cyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of T14 and Y15. Cyclin A, B - Cdc2 complexes phosphorylate several proteins involved in mitotic spindle structure and function, the breakdown of the nuclear envelope, and topological changes in chromosomes al
Last changed: 2015-03-06 23:15:47

Reaction: Association of NuMA with microtubules (Homo sapiens)
NuMA can interact with microtubules by direct binding to tubulin. Binding occurs through amino acids 1868-1967 of human NuMA (tail IIA) and appears to play a role in the organization of the spindle poles by stably crosslinking microtubule fibers (Haren and Merdes 2002). While the exact mechanism of microtubule bundling is not known, NuMA has been shown to form large fibrous networks (Saredi et al.,
Last changed: 2015-03-06 10:40:16

Reaction: Cyclin B/Cdk1 mediate phosphorylation of NuMA (Homo sapiens)
After the initiation of DNA condensation during mitosis, NuMA is phosphorylated by Cdc2 kinase and transported rapidly to the centrosomal region (Hsu and Yeh, 1996). Another phosphorylation event occurs when NuMA associates with the mitotic spindle (Gaglio et al., 1995; Hsu and Yeh, 1996). While p34cdc2/cyclin B-dependent phosphorylation appears to plays an essential role in the targeting of NuMA
Last changed: 2015-03-06 10:40:16

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