Reactome: A Curated Pathway Database
All 5 results
Pathways (0) Reactions (0) Proteins (3) Others (2)
Protein: UniProt:Q8NFM7 IL17RD (Homo sapiens)
Last changed: 2015-03-10 08:59:22

Protein: UniProt:Q8NFM7-1 IL17RD (Homo sapiens)
Last changed: 2015-03-10 08:59:22

Protein: UniProt:Q8NFM7-4 IL17RD (Homo sapiens)
Last changed: 2015-03-10 08:59:22

Inhibition: 'IL17RD [cytosol]' negatively regulates 'p-MEK phosphorylates ERK'
IL17RD, or SEF, is a negative regulator of FGF signaling. There are at least two isoforms in humans, a transmembrane version and a cytosolic splice variant. SEF appears to function at multiple points in the FGFR pathway, perhaps dependent on cell type. SEF appears to attenuate signaling through the MAPK pathway, although the precise point of action remains to be clarified. Some reports have indicat
Last changed: 2011-05-09 20:50:43

Inhibition: 'IL17RD [Golgi membrane]' negatively regulates 'Dissociation of p-ERK from p-MEK'
One report has suggested that the plasma membrane form of IL17RD (SEF) acts as a spatial regulator of ERK signaling by preventing the dissociation of activated ERK1/2 from the MEK1/2 complex. As a result, ERK1/2 can not translocate into the nucleus and activation of nuclear, but not cytoplasmic targets, is abrogated
Last changed: 2011-05-09 20:50:35