Reactome: A Curated Pathway Database
All 6 results
Pathways (3) Reactions (1) Proteins (1) Others (1)
Protein: UniProt:Q8WYB5 KAT6B (Homo sapiens)
Last changed: 2014-11-26 10:20:21

Pathway: Chromatin organization (Homo sapiens)
Chromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance of the physical structure of eukaryotic chromatin. These processes include histone modification, DNA modification, and transcription. The modifications are bound by specific proteins that alter the conformat
Last changed: 2014-11-21 19:49:01

Pathway: Chromatin modifying enzymes (Homo sapiens)
Eukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect it from damage. Access to DNA is achieved by highly regulated local chromatin decondensation. The 'building block' of chromatin is the nucleosome. This contains ~150 bp of DNA wrapped around a histon
Last changed: 2014-11-21 19:49:01

Pathway: HATs acetylate histones (Homo sapiens)
Histone acetyltransferases (HATs) involved in histone modifications are referred to as A-type or nuclear HATs. They can be grouped into at least four families based on sequence conservation within the HAT domain: Gcn5/PCAF, MYST, p300/CBP and Rtt109. The p300/CBP and Rtt109 families are specific to metazoans and fungi respectively (Marmorstein & Trievel 2009). Gcn5/PCAF and MYST family members have no
Last changed: 2014-11-21 19:49:01

Reaction: KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3 (Homo sapiens)
KAT6A (Monocytic leukemia zinc finger protein, MOZ) and KAT6B (Monocytic leukemia zinc finger protein-related factor, MORF) are member of the MYST family of histone acetyltransferases, named after the founding members MOZ, Ybf2/Sas3, Sas2 and TIP60 (Borrow et al. 1996, Reifsnyder et al. 1996). The presence of a MYST domain is the only common structural motif in this family. MOZ and MORF are highly homo
Last changed: 2014-11-21 19:49:01

Complex: KAT6:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
KAT6:ING5:MEAF6:BRPF1,(2,3); KAT6-ING5 complex; KAT6A,KAT6B:ING5:MEAF6:BRPF1,(BRPF2,BRPF3)
Last changed: 2013-05-02 09:05:59