Reactome: A Curated Pathway Database
All 6 results
Pathways (4) Reactions (1) Proteins (1) Others (0)
Protein: UniProt:Q92581 SLC9A6 (Homo sapiens)
Last changed: 2015-03-10 08:59:22

Pathway: Transmembrane transport of small molecules (Homo sapiens)
Last changed: 2015-03-06 23:15:47

Pathway: Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Teleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively inorganic cations and anions across membranes : SLC4 plays a pivotal role in mediating Na+ - and/or Cl- -dependent transport of basic anions [e.g. HCO3-, (CO3)2-] in various tissues and cell types (in additi
Last changed: 2015-03-06 23:15:47

Pathway: SLC-mediated transmembrane transport (Homo sapiens)
Proteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the movement of the substrates across the membrane, against their electrochemical gradient. Channels at the open state can transfer the substrates (ions or water) down their electrochemical gradient, at an extre
Last changed: 2015-03-06 23:15:47

Pathway: Sodium/Proton exchangers (Homo sapiens)
The SLC9 gene family encode proteins (sodium/proton exchangers, NHE or NHX) which exchange sodium (influx) for protons (efflux) electroneutrally. This mechanism is important because many metabolic processes generate acids which need to be removed to maintain pH. This is the major proton extruding system in cells, driven by the inward sodium ion chemical gradient. To date, there are eleven NHE genes, NH
Last changed: 2015-03-06 23:15:47

Reaction: SLC9A6,7 exchange Na+ for H+ across the early endosome membrane (Homo sapiens)
NHE6 (SLC9A6) (Brett CL et al, 2002; Nakamura N et al, 2005) is expressed ubiquitously and thought to play a housekeeping role in pH homeostasis in early endosomes
Last changed: 2015-03-06 23:15:47