Reactome: A Curated Pathway Database
All 10 results
Pathways (5) Reactions (2) Proteins (1) Others (2)
Protein: UniProt:Q96BD5 PHF21A (Homo sapiens)
Last changed: 2015-03-10 08:59:22

Pathway: Hemostasis (Homo sapiens)
Hemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in character. Under acute vascular trauma, vasoconstrictor mechanisms predominate and the endothelium becomes p
Last changed: 2015-03-06 23:15:47

Pathway: Chromatin organization (Homo sapiens)
Chromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance of the physical structure of eukaryotic chromatin. These processes include histone modification, DNA modification, and transcription. The modifications are bound by specific proteins that alter the conformat
Last changed: 2015-03-06 23:15:47

Pathway: Factors involved in megakaryocyte development and platelet production (Homo sapiens)
Megakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they undergo endoreduplication (polyploidisation) and expansion of cytoplasmic mass to cell sizes larger than 50-100 microns, and ploidy ranges up to 128 N. As MK's mature, the polyploid nucleus becomes horseshoe-shap
Last changed: 2015-03-06 23:15:47

Pathway: Chromatin modifying enzymes (Homo sapiens)
Eukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect it from damage. Access to DNA is achieved by highly regulated local chromatin decondensation. The 'building block' of chromatin is the nucleosome. This contains ~150 bp of DNA wrapped around a histon
Last changed: 2015-03-06 23:15:47

Pathway: HDACs deacetylate histones (Homo sapiens)
Lysine deacetylases (KDACs), historically referred to as histone deacetylases (HDACs), are divided into the Rpd3/Hda1 metal-dependent 'classical HDAC family' (de Ruijter et al. 2003, Verdin et al. 2003) and the unrelated sirtuins (Milne & Denu 2008). Phylogenetic analysis divides human KDACs into four classes (Gregoretti et al. 2004): Class I includes HDAC1, 2, 3 and 8; Class IIa includes HDAC4, 5, 7
Last changed: 2015-03-06 00:07:54

Reaction: HDAC1/2 containing-complexes deacetylate histones (Homo sapiens)
HDAC1 and HDAC2 interact to form the catalytic core of several multisubunit complexes including the Sin3, nucleosome remodeling deacetylase (NuRD) and corepressor of REST (CoREST) complexes (Grozinger & Schreiber 2002). A 'core complex' of HDAC1/2 and the histone binding proteins RBBP7 (RbAp46) and RBBP4 (RbAp48), has been described in vivo and in vitro (Zhang et al. 1999). The Sin3 complex consists of
Last changed: 2015-03-06 00:07:54

Reaction: REST recruits the BHC complex (Homo sapiens)
The BHC (BRAF-HDAC) complex is involved in the repression of neuronal-specific genes during development. It is recruited by RE1-silencing transcription factor (REST) to mediate the repression of REST-responsive genes. The BHC complex includes histone deacetylases (HDACs) 1 and 2, and the histone demethylase KDM1A (also knowns as BHC110, LSD1 or AOF2). KDM1A demethylates both Lys-4 (H3K4me) and Lys-9 (H
Last changed: 2015-03-06 18:40:03

Complex: BHC complex:REST:REST DNA binding sites [nucleoplasm] (Homo sapiens)
BHC complex:REST:REST DNA binding sites
Last changed: 2013-11-08 10:33:36

Complex: BHC complex [nucleoplasm] (Homo sapiens)
BHC complex; BRAF-HDAC complex
Last changed: 2013-10-04 12:24:18