Reactome: A Curated Pathway Database
Results 1 to 10 of 13
Pathways (6) Reactions (3) Proteins (1) Others (3)
Protein: UniProt:Q96QK1 VPS35 (Homo sapiens)
Last changed: 2014-11-25 09:29:35

Pathway: Disease (Homo sapiens)
Biological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular viewpoint, human disease pathways have three mechanistic causes: the inclusion of microbially-expressed proteins, altered functions of human proteins, or changed expression levels of otherwise functionally
Last changed: 2014-11-21 19:49:01

Pathway: Signal Transduction (Homo sapiens)
Signal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such as hormones and growth factors, or reacting to other types of stimuli, such as light. Stimulation of transmembrane receptors leads to their conformational change which propagates the signal to the intracellu
Last changed: 2014-11-21 19:49:01

Pathway: WNT ligand biogenesis and trafficking (Homo sapiens)
19 WNT proteins have been identified in human cells. The WNTs are members of a conserved metazoan family of secreted morphogens that activate several signaling pathways in the responding cell: the canonical (beta-catenin) WNT signaling cascade and several non-canonical pathways, including the planar cell polarity (PCP), the regulation of intracellular calcium signaling and activation of JNK kinases.
Last changed: 2014-11-21 14:40:22

Pathway: WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 (Homo sapiens)
Aberrant WNT signaling is associated with the development of numerous cancers, and strategies for targeting this pathway are under intense investigation (reviewed in Polakis, 2012; Polakis, 2000; Yao et al, 2011). Secretion of WNT ligand depends on its PORCN-dependent palmitoleoylation in the ER, making PORCN a attractive therapeutic target in cases where WNT is aberrantly over-expressed (reviewed in
Last changed: 2014-11-21 14:40:22

Pathway: Signaling by Wnt (Homo sapiens)
WNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Saito-Diaz et al, 2013; MacDonald et al, 2009). The pathway is named for the WNT ligands, a large family of secreted cysteine-rich glycoproteins. At least 19 WNT members have been identified in humans and mic
Last changed: 2014-11-21 14:40:22

Pathway: Signaling by WNT in cancer (Homo sapiens)
The WNT signaling pathway has been linked with cancer ever since the identification of the first WNT as a gene activated by integration of mouse mammary tumor virus proviral DNA in virally-induced breast tumors (Nusse et al, 1984). The most well known example of aberrant WNT signaling in cancer is in colorectal cancer, where an activating mutation in a WNT pathway component is seen in 90% of sporadic
Last changed: 2014-11-21 14:40:22

Reaction: Retromer associates with WLS (Homo sapiens)
Retromer is a conserved multi-protein complex that is required for retrograde transport of transmembrane proteins. It was initially characterized in yeast as a pentameric complex required for the recycling of the transmembrane receptor VPS10 to the trans-Golgi, and was subsequently shown to be conserved in flies, worms and humans. In humans, retromer consists of a cargo-recognition subcomplex made up
Last changed: 2014-11-21 06:36:34

Reaction: Retromer recycles WLS to the Golgi (Homo sapiens)
Retromer is believed to escort WLS from the early endosome back to the Golgi for subsequent rounds of WNT secretion (reviewed in Johannes and Wunder, 2011; Willert and Nusse, 2012 )
Last changed: 2014-11-21 14:40:22

Reaction: WLS dissociates from retromer (Homo sapiens)
Although the role of retromer in delivering WLS back to the Golgi is reasonably well established (reviewed in Johannes and Wunder, 2011; Willert and Nusse, 2012), the details of how the complex is disassembled at the TGN remain to be determined
Last changed: 2014-11-21 06:36:34

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