Reactome: A Curated Pathway Database
All 5 results
Pathways (2) Reactions (1) Proteins (1) Others (1)
Protein: UniProt:Q96SL4 GPX7 (Homo sapiens)
Last changed: 2015-03-10 08:59:22

Pathway: Cellular responses to stress (Homo sapiens)
Cells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissues to modulate molecular processes in response to such external stresses is essential to the maintenance of tissue homeostasis (Kultz 2005)
Last changed: 2015-03-06 23:15:47

Pathway: Detoxification of Reactive Oxygen Species (Homo sapiens)
Reactive oxygen species such as superoxide (O2.-), peroxides (ROOR), singlet oxygen, peroxynitrite (ONOO-), and hydroxyl radical (OH.) are generated by cellular processes such as respiration (reviewed in Murphy 2009, Brand 2010) and redox enzymes and are required for signaling yet they are damaging due to their high reactivity (reviewed in Imlay 2008, Buettner 2011, Kavdia 2011, Birben et al. 2012, Ray
Last changed: 2015-03-06 23:15:47

Reaction: GPX7,8 catalyze peroxidation of P4HB (PDI) (Homo sapiens)
Glutathione peroxidase 7 (GPX7) and GPX8 are atypical glutathione peroxidases that catalyze the peroxidation of protein disulfide isomerases, such as PDI (P4HB) (Nguyen et al. 2011 and inferred from mouse in Bosello-Travain et al. 2013). GPX7 and GPX8 are each able to form heterodimers with the sulfhydryl oxidase ERO1alpha (ERO1L) in the endoplasmic reticulum lumen. It is hypothesized that GPX7 and GPX
Last changed: 2015-03-06 10:40:16

Complex: ERO1L:GPX7,8 [endoplasmic reticulum lumen] (Homo sapiens)
Last changed: 2013-05-12 10:45:15