Reactome: A Curated Pathway Database
All 10 results
Pathways (6) Reactions (2) Proteins (1) Others (1)
Protein: UniProt:Q9NQC7 CYLD (Homo sapiens)
Last changed: 2014-11-26 10:20:21

Pathway: Immune System (Homo sapiens)
Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system
Last changed: 2014-11-21 19:49:01

Pathway: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways (Homo sapiens)
RIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. Functionally RIG-I and MDA5 positively regulate the IFN genes in a similar fashion, however they differ in their response to different viral species. RIG-I is essential for detecting influenza virus, Sendai
Last changed: 2014-11-21 14:40:22

Pathway: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
The innate immune system is the first line of defense against invading microorganisms, a broad specificity response characterized by the recruitment and activation of phagocytes and the release of anti-bacterial peptides. The receptors involved recognize conserved molecules present in microbes called pathogen-associated molecular patterns (PAMPs), and/or molecules that are produced as a result of tissu
Last changed: 2014-11-21 19:49:01

Pathway: Innate Immune System (Homo sapiens)
Innate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
Last changed: 2014-11-21 19:49:01

Pathway: NOD1/2 Signaling Pathway (Homo sapiens)
NOD1 is ubiquitously expressed, while NOD2 expression is restricted to monocytes, macrophages, dendritic cells, and intestinal Paneth cells (Inohara et al. 2005). NOD1 and NOD2 activation induces transcription of immune response genes, predominantly mediated by the proinflammatory transcriptional factor NFkappaB but also by AP-1 and Elk-1 (Inohara et al. 2005). NFkappaB translocates to the nucleus foll
Last changed: 2014-11-21 14:40:22

Pathway: Negative regulators of RIG-I/MDA5 signaling (Homo sapiens)
As with other cytokine systems, production of type I IFN is a transient process, and can be hazardous to the host if unregulated, resulting in chronic cellular toxicity or inflammatory and autoimmune diseases. RIG-I-mediated production of IFN can, in turn, increase the transcription of RIG-I itself, thus setting into motion an IFN amplification loop, which if left unchecked, could become deleterious to
Last changed: 2014-11-21 06:36:34

Reaction: CYLD deubiquitinates NEMO (Homo sapiens)
RIP2-induced ubiquitination of NEMO and consequent NFkappaB activation can be reversed in a dose-responsive manner by the deubiquitinase CYLD, suggesting that CYLD negatively regulates RIP2-induced NEMO ubiquitinylation
Last changed: 2014-11-21 06:36:34

Reaction: CYLD mediated deubiquitination of RIG-I (Homo sapiens)
CYLD is an ovarian tumor (OTU) domain-containing deubiquitinating enzyme (DUB) and has been identified as a negative regulator of RIG-I mediated antiviral signaling. CYLD associates with the CARD domain of RIG-I and removes K63-linked ubiquitin from the RIG-I CARDs that are conjugated by the E3 ubiquitin ligase, TRIM25 and RNF135
Last changed: 2014-11-21 03:10:46

Activation: 'RIP1 deubiquitinases [cytosol]' positively regulates 'TRADD:TRAF2:RIP1 complex binds FADD'
Last changed: 2014-11-07 03:05:00