Reactome: A Curated Pathway Database
Results 1 to 10 of 18
Pathways (9) Reactions (4) Proteins (1) Others (4)
Protein: UniProt:Q9UIQ6 LNPEP (Homo sapiens)
Last changed: 2015-03-12 14:00:50

Pathway: Vesicle-mediated transport (Homo sapiens)
Last changed: 2015-03-06 23:15:47

Pathway: Immune System (Homo sapiens)
Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system
Last changed: 2015-03-06 23:15:47

Pathway: Class I MHC mediated antigen processing & presentation (Homo sapiens)
Major histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular bacteria or tumor-associated antigens. They bind peptide fragments of these proteins and presenting them to CD8+ T cells at the cell surface. This enables cytotoxic T cells to identify and eliminate cells th
Last changed: 2015-03-06 23:15:47

Pathway: Membrane Trafficking (Homo sapiens)
The secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is made up of distinct organelles, including the endoplasmic reticulum (ER), Golgi complex, plasma membrane, and tubulovesicular transport intermediates. These organelles mediate intracellular membrane transport
Last changed: 2015-03-06 23:15:47

Pathway: Translocation of GLUT4 to the plasma membrane (Homo sapiens)
In adipocytes and myocytes insulin signaling causes intracellular vesicles carrying the GLUT4 (SLC2A4) glucose transporter to translocate to the plasma membrane, allowing the cells to take up glucose from the bloodstream (reviewed in Zaid et al. 2008, Leney and Tavare 2009, Bogan and Kandror 2010, Foley et al. 2011, Hoffman and Elmendorf 2011, Kandror and Pilch 2011). In myocytes muscle contraction alo
Last changed: 2015-03-06 23:15:47

Pathway: Adaptive Immune System (Homo sapiens)
Adaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with remarkable diversity tailored to recognize aspects of particular pathogens or antigens. During infection, dendritic cells (DC) which act as sentinels in the peripheral tissues recognize and pick up the pat
Last changed: 2015-03-06 23:15:47

Pathway: Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Intracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T cells. The ubiquitin-26S proteasome system plays a central role in the generation of these class I MHC antigens. Ubiquitination is the mechanism of adding ubiquitin to lysine residues on substrate prote
Last changed: 2015-03-06 23:15:47

Pathway: Endosomal/Vacuolar pathway (Homo sapiens)
Some antigens are cross-presented through a vacuolar mechanism that involves generation of antigenic peptides and their loading on to MHC-I molecules within the endosomal compartment in a proteasome and TAP-independent manner. Antigens within the endosome are processed by cathepsin S and other proteases into antigenic peptides. Loading of these peptides onto MHC-I molecules occurs directly within early
Last changed: 2015-03-06 23:15:47

Pathway: Antigen processing-Cross presentation (Homo sapiens)
MHC class I molecules generally present peptide antigens derived from proteins synthesized by the cell itself to CD8+ T cells. However, in some circumstances, antigens from extracellular environment can be presented on MHC class I to stimulate CD8+ T cell immunity, a process termed cross-presentation (Rock & Shen. 2005). Cross-presentation/cross-priming is the ability of antigen presenting cells (APCs)
Last changed: 2015-03-06 23:15:47

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