Reactome: A Curated Pathway Database
Results 1 to 10 of 16
Pathways (12) Reactions (3) Proteins (1) Others (0)
Protein: UniProt:Q9UNU6 CYP8B1 (Homo sapiens)
Last changed: 2015-03-10 08:59:22

Pathway: Metabolism (Homo sapiens)
Metabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as the inactivation and elimination of toxic ones generated endogenously or present in the extracellular environment. The processes of energy metabolism can be classified into two groups according to whether the
Last changed: 2015-03-06 23:15:47

Pathway: Bile acid and bile salt metabolism (Homo sapiens)
In a healthy adult human, about 500 mg of cholesterol is converted to bile salts daily. Newly synthesized bile salts are secreted into the bile and released into the small intestine where they emulsify dietary fats (Russell 2003). About 95% of the bile salts in the intestine are recovered and returned to the liver (Kullak-Ublick et al. 2004; Trauner and Boyer 2002). The major pathway for bile salt synt
Last changed: 2015-03-06 23:15:47

Pathway: Biological oxidations (Homo sapiens)
All organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ingestion but inhalation and transdermal routes are also common. The very nature of many chemicals that make them suitable for uptake by these routes, in other words their lipophilicty (favours fat so
Last changed: 2015-03-06 23:15:47

Pathway: Metabolism of lipids and lipoproteins (Homo sapiens)
Lipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphingolipids, eicosanoids, cholesterol, bile salts, steroid hormones, and fat-soluble vitamins. They function as a major source of energy (fatty acids, triacylglycerols, and ketone bodies), are major constitue
Last changed: 2015-03-06 23:15:47

Pathway: Phase 1 - Functionalization of compounds (Homo sapiens)
Phase 1 of metabolism is concerned with functionalization , that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conjugating species with which to react with. Many xenobiotics are lipophilic and almost chemically inert (e.g. PAHs) so would not necessarily undergo a phase 2 reaction. Making them more chemical
Last changed: 2015-03-06 23:15:47

Pathway: Sterols are 12-hydroxylated by CYP8B1 (Homo sapiens)
Cytochrome P450 8B1 (CYP8B1, sterol 12-alpha- hydroxylase) has a broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids. It is also involved in bile acid synthesis and is responsible for the balance between the formation of cholic acid and chenodeoxycholic acid (Gafvels et al. 1999)
Last changed: 2015-03-06 10:40:16

Pathway: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)
In the liver, synthesis of bile acids and bile salts is initiated with the conversion of cholesterol to 7alpha-hydroxycholesterol and of 7alpha-hydroxycholesterol to 4-cholesten-7alpha-ol-3-one. The pathway then branches: hydroxylation of 4-cholesten-7alpha-ol-3-one to 4-cholesten-7alpha, 12alpha-diol-3-one leads ultimately to the formation of cholate, while its reduction to 5beta-cholestan-7alpha-ol-3
Last changed: 2015-03-06 23:15:47

Pathway: Synthesis of bile acids and bile salts (Homo sapiens)
In a healthy adult human, about 500 mg of cholesterol is converted to bile salts daily (Russell 2003). The major pathway for bile salt synthesis in the liver begins with the conversion of cholesterol to 7alpha-hydroxycholesterol. Bile salt synthesis can also begin with the synthesis of an oxysterol - 24-hydroxycholesterol or 27-hydroxycholesterol. In the body, the initial steps of these two pathways oc
Last changed: 2015-03-06 23:15:47

Pathway: Cytochrome P450 - arranged by substrate type (Homo sapiens)
The P450 isozyme system is the major phase 1 biotransforming system in man, accounting for more than 90% of drug biotransformations. This system has huge catalytic versatility and a broad substrate specificity, acting upon xenobiotica and endogenous compounds. It is also called the mixed-function oxidase system, the P450 monooxygenases and the heme-thiolate protein system. All P450 enzymes are a gr
Last changed: 2015-03-06 23:15:47

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