Reactome: A Curated Pathway Database
Results 1 to 10 of 68
Pathways (23) Reactions (28) Proteins (1) Others (16)
Protein: UniProt:Q9Y2S0 POLR1D (Homo sapiens)
Last changed: 2015-03-10 08:49:45

Pathway: Gene Expression (Homo sapiens)
Gene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are processed. Most annotation is centered on the generation of messenger RNAs (mRNAs) by regulated RNA polymerase II (PolII) transcription, although the activities of PolI and PolIII are also covered briefly, as are
Last changed: 2015-03-06 23:15:47

Pathway: Immune System (Homo sapiens)
Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system
Last changed: 2015-03-06 23:15:47

Pathway: NoRC negatively regulates rRNA expression (Homo sapiens)
Only about half of the rRNA gene copies in a cell are expressed. The remaining copies are silenced by modifications to histones and DNA (reviewed in Santoro and Grummt 2001, Grummt 2007, Preuss and Pikaard 2007, Birch and Zomerdijk 2008, McStay and Grummt 2008, Grummt and Langst 2013). The promoters of silenced rRNA gene copies have methylated cytosine and histone H3 dimethylated at lysine-9. As inferr
Last changed: 2015-03-06 10:40:16

Pathway: Epigenetic regulation of gene expression (Homo sapiens)
Epigenetic processes regulate gene expression by modulating the frequency, rate, or extent of gene expression in a mitotically or meiotically heritable way that does not entail a change in the DNA sequence. Originally the definition applied only to heritability across generations but later also encompassed the heritable changes that occur during cellular differentiation within one organism. Molecul
Last changed: 2015-03-06 18:40:03

Pathway: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription (Homo sapiens)
Transcription by RNA Polymerase I, RNA Polymerase III and transcription from mitochondrial promoters
Last changed: 2015-03-06 23:15:47

Pathway: Innate Immune System (Homo sapiens)
Innate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
Last changed: 2015-03-06 23:15:47

Pathway: Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
Presence of pathogen-associated DNA in cytosol induces type I IFN production. Several intracellular receptors have been implicated to some degree. These include DNA-dependent activator of interferon (IFN)-regulatory factors (DAI) (also called Z-DNA-binding protein 1, ZBP1), absent in melanoma 2 (AIM2), RNA polymerase III (Pol III), IFN-inducible protein IFI16, leucine-rich repeat flightless interacting
Last changed: 2015-03-06 23:15:47

Pathway: Negative epigenetic regulation of rRNA expression (Homo sapiens)
Transcription of rRNA genes is controlled by epigenetic activation and repression (reviewed in McStay and Grummt 2008, Goodfellow and Zomerdijk 2012, Grummt and Langst 2013). About half of the roughly 400 rRNA genes are expressed and these have the modifications of active chromatin: unmethylated DNA and acetylated histones. Repressed genes generally have methylated DNA and histone H3 methylated at lysi
Last changed: 2015-03-06 10:40:16

Pathway: Transcription (Homo sapiens)
Transcription by RNA Polymerase I, RNA Polymerase III and transcription from mitochondrial promoters
Last changed: 2015-03-06 23:15:47

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