Reactome: A Curated Pathway Database
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Pathways (15) Reactions (12) Proteins (1) Others (17)
Protein: UniProt:Q9Y5S9 RBM8A (Homo sapiens)
Last changed: 2015-03-12 12:55:37

Pathway: Gene Expression (Homo sapiens)
Gene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are processed. Most annotation is centered on the generation of messenger RNAs (mRNAs) by regulated RNA polymerase II (PolII) transcription, although the activities of PolI and PolIII are also covered briefly, as are
Last changed: 2015-03-06 23:15:47

Pathway: RNA Polymerase II Transcription (Homo sapiens)
Last changed: 2015-03-06 23:15:47

Pathway: Nonsense-Mediated Decay (NMD) (Homo sapiens)
The Nonsense-Mediated Decay (NMD) pathway activates the destruction of mRNAs containing premature termination codons (PTCs) (reviewed in Isken and Maquat 2007, Chang et al. 2007, Behm-Ansmant et al. 2007, Neu-Yilik and Kulozik 2008, Rebbapragada and Lykke-Andersen 2009, Bhuvanagiri et al. 2010, Nicholson et al. 2010, Durand and Lykke-Andersen 2011). In mammalian cells a termination codon can be recogni
Last changed: 2015-03-06 23:15:47

Pathway: Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Co-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per gene, which cannot serve as splicing substrates until both 5' and 3' ends of each intron are synthesized. Thus the time that it takes for pol II to synthesize each intron defines a minimal time and distance a
Last changed: 2015-03-06 23:15:47

Pathway: Post-Elongation Processing of the Transcript (Homo sapiens)
Post-transcriptional splicing of introns is affected neither by the elongating properties of RNA polymerase II, nor by the binding of splicing regulatory factors to the enzyme. It is only affected by the relative abundance of constitutive and/or regulatory splicing factors at the sites where splicing takes place. Nevertheless it is important to point out that cytological evidence indicates that unsplic
Last changed: 2015-03-06 23:15:47

Pathway: Transcription (Homo sapiens)
Transcription by RNA Polymerase I, RNA Polymerase III and transcription from mitochondrial promoters
Last changed: 2015-03-06 23:15:47

Pathway: Cleavage of Growing Transcript in the Termination Region (Homo sapiens)
This section includes the cleavage of both polyadenylated and non-polyadenylated transcripts. In the former case polyadenylation has to precede transcript cleavage, while in the latter case there is no polyadenylation
Last changed: 2015-03-06 18:40:03

Pathway: mRNA Splicing - Major Pathway (Homo sapiens)
The splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the range of 3-5 million kDa. Small nuclear RNAs (snRNAs) U1, U2, U4, U5, and U6, are some of the best characterized components of spliceosomes, and are known to play key roles not only in spliceosomal assembl
Last changed: 2015-03-06 23:15:47

Pathway: RNA Polymerase II Transcription Termination (Homo sapiens)
The detailed annotation of this section will be completed in the next release
Last changed: 2015-03-06 18:40:03

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