Reactome: A Curated Pathway Database
All 7 results
Pathways (4) Reactions (1) Proteins (1) Others (1)
Protein: UniProt:P07741 APRT (Homo sapiens)
Last changed: 2015-03-12 12:55:37

Pathway: Metabolism (Homo sapiens)
Metabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as the inactivation and elimination of toxic ones generated endogenously or present in the extracellular environment. The processes of energy metabolism can be classified into two groups according to whether the
Last changed: 2015-03-06 23:15:47

Pathway: Metabolism of nucleotides (Homo sapiens)
Nucleotides and their derivatives are used for short-term energy storage (ATP, GTP), for intra- and extra-cellular signaling (cAMP; adenosine), as enzyme cofactors (NAD, FAD), and for the synthesis of DNA and RNA. Most dietary nucleotides are consumed by gut flora; the human body's own supply of these molecules is synthesized de novo. Additional metabolic pathways allow the interconversion of nucleotid
Last changed: 2015-03-06 23:15:47

Reaction: Adenine + PRPP => AMP + PPi (Homo sapiens)
Cytosolic APRT dimer catalyzes the reaction of adenine and 5-phospho-alpha-D-ribose 1-diphosphate to form AMP and pyrophosphate (Holden et al. 1979)
Last changed: 2015-03-12 13:50:51

Pathway: Purine salvage (Homo sapiens)
Nucleosides and free bases generated by DNA and RNA breakdown are converted back to nucleotide monophosphates, allowing them to re-enter the pathway of purine biosynthesis. Nucleosides and free bases generated by DNA breakdown are converted back to nucleotide monophosphates, allowing them to re-enter the pathway of purine biosynthesis. Nucleosides and free bases generated by RNA breakdown are converted
Last changed: 2015-03-06 23:15:47

Pathway: Purine metabolism (Homo sapiens)
The events of human purine metabolism are conveniently, if somewhat arbitrarily, grouped into four pathways: de novo synthesis of inosine 5'-monophosphate (IMP), the biosynthesis of other purine ribo- and deoxyribonucleotides, purine salvage reactions, and purine catabolism (Watts 1974). De novo synthesis of inosine 5'-monophosphate (IMP). The purine ribonucleotide IMP is assembled on 5-phosp
Last changed: 2015-03-06 23:15:47

Complex: APRT homodimer [cytosol] (Homo sapiens)
APRT homodimer
Last changed: 2004-11-12 05:53:46