Reactome: A Curated Pathway Database
All 10 results
Pathways (5) Reactions (2) Proteins (3) Others (0)
Protein: UniProt:O60260 PARK2 (Homo sapiens)
Last changed: 2015-03-12 12:55:37

Pathway: Metabolism (Homo sapiens)
Metabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as the inactivation and elimination of toxic ones generated endogenously or present in the extracellular environment. The processes of energy metabolism can be classified into two groups according to whether the
Last changed: 2015-03-06 23:15:47

Pathway: Metabolism of carbohydrates (Homo sapiens)
These pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the body (as glycogen) and its mobilization during a short fast; and 3) the synthesis of glucose from pyruvate during extended fasts
Last changed: 2015-03-06 23:15:47

Pathway: Glycosaminoglycan metabolism (Homo sapiens)
Glycosaminoglycans (GAGs) are long, unbranched polysaccharides containing a repeating disaccharide unit composed of a hexosamine (either N-acetylgalactosamine (GalNAc) or N-acetylglucosamine (GlcNAc)) and a uronic acid (glucuronate or iduronate). They can be heavily sulfated. GAGs are located primarily in the extracellular matrix (ECM) and on cell membranes, acting as a lubricating fluid for joints and
Last changed: 2015-03-06 23:15:47

Pathway: Chondroitin sulfate biosynthesis (Homo sapiens)
Chondroitin sulfate (CS) glycosaminoglycan consists of N-acetylgalactosamine (GalNAc) residues alternating in glycosidic linkages with glucuronic acid (GlcA). GalNAc residues are sulfated to varying degrees on 4- and/or 6- positions. The steps below describe the biosynthesis of a simple CS molecule (Pavao et al. 2006, Silbert & Sugumaran 2002)
Last changed: 2015-03-06 18:40:03

Pathway: Chondroitin sulfate/dermatan sulfate metabolism (Homo sapiens)
Chondroitin sulfate (CS) is a sulfated glycosaminoglycan (GAG). CS chains are unbranched polysaccharides of varying length containing two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc). The chains are usually attached to proteins forming a proteoglycan. CS is an important structural component of cartilage due to it's ability to withstand compression. It is a
Last changed: 2015-03-06 23:15:47

Reaction: CHPF,CHPF2,CHSY1,CHSY3 transfer GlcA to chondroitin (Homo sapiens)
A glucuronate (GlcA) moiety is added to the chondroitin chain by dual-activity enzymes, the chondroitin sulfate synthases 1-3 (CHSY1, CHPF and CHSY3) (Kitagawa et al. 2001, Yada et al. 2003, Yada et al. 2003b). They possess both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. These three enzymes require divalent metals as cofactors, manganese producing the highest acti
Last changed: 2015-03-06 18:40:03

Reaction: CHPF,CHSY1,CHSY3 transfer GalNAc to chondroitin (Homo sapiens)
An N-acetylgalactosamine (GalNAc) moiety is added to the chondroitin chain by dual-activity enzymes, the chondroitin sulfate synthases 1-3 (CHSY1, CHPF and CHSY3 respectively) (Kitagawa et al. 2001, Yada et al. 2003, Yada et al. 2003b). They possess both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity, the latter activity used in this reaction. These three enzymes requi
Last changed: 2015-03-06 18:40:03

Protein: UniProt:Q6NUN9 ZNF746 (Homo sapiens)
Last changed: 2015-03-10 08:59:22

Protein: UniProt:Q8IZ52 CHPF (Homo sapiens)
Last changed: 2015-03-10 08:59:22