Reactome: A Curated Pathway Database
All 7 results
Pathways (4) Reactions (0) Proteins (1) Others (2)
Pathway: Metabolism (Homo sapiens)
Metabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as the inactivation and elimination of toxic ones generated endogenously or present in the extracellular environment. The processes of energy metabolism can be classified into two groups according to whether the
Last changed: 2015-03-06 23:15:47

Pathway: Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
Oxidation of fatty acids and pyruvate in the mitochondrial matrix yield large amounts of NADH. The respiratory electron transport chain couples the re-oxidation of this NADH to NAD+ to the export of protons from the mitochonrial matrix, generating a chemiosmotic gradient across the inner mitochondrial membrane. This gradient is used to drive the synthesis of ATP; it can also be bypassed by uncoupling p
Last changed: 2015-03-06 23:15:47

Pathway: The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
The metabolism of pyruvate provides one source of acetyl-CoA which enters the citric acid (TCA, tricarboxylic acid) cycle to generate energy and the reducing equivalent NADH. These reducing equivalents are re-oxidized back to NAD+ in the electron transport chain (ETC), coupling this process with the export of protons across the inner mitochondrial membrane. The chemiosmotic gradient created is used to
Last changed: 2015-03-06 23:15:47

Pathway: Mitochondrial Uncoupling Proteins (Homo sapiens)
Uncoupling proteins (UCPs) are members of the mitochondrial transport carrier family, and have been implicated in a wide range of physiological and pathological conditions. Physiological conditions include thermogenesis, fatty acid metabolism and protection against free radicals and ageing; pathological conditions include involvement in obesity, diabetes and degenerative, neurological and immunological
Last changed: 2015-03-06 23:15:47

Protein: UniProt:Q86Z02 HIPK1 (Homo sapiens)
Last changed: 2015-03-12 14:00:50

Activation: 'NKX2-5:GATA4:HIPK1,2 [nucleoplasm]' positively regulates 'Expression of NPPA (ANF)'
Last changed: 2014-06-04 09:32:08

Complex: NKX2-5:GATA4:HIPK1,2 [nucleoplasm] (Homo sapiens)
Last changed: 2014-06-04 09:32:08