Reactome: A Curated Pathway Database
Results 1 to 10 of 33
Pathways (12) Reactions (11) Proteins (2) Others (8)
Protein: UniProt:P52945 PDX1 (Homo sapiens)
Last changed: 2014-11-25 09:29:35

Pathway: Signal Transduction (Homo sapiens)
Signal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such as hormones and growth factors, or reacting to other types of stimuli, such as light. Stimulation of transmembrane receptors leads to their conformational change which propagates the signal to the intracellu
Last changed: 2014-11-21 19:49:01

Pathway: Metabolism (Homo sapiens)
Metabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as the inactivation and elimination of toxic ones generated endogenously or present in the extracellular environment. The processes of energy metabolism can be classified into two groups according to whether the
Last changed: 2014-11-21 19:49:01

Pathway: Developmental Biology (Homo sapiens)
As a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are aspects of the roles of cell adhesion molecules in axonal guidance and myogenesis, of transcriptional regulation in hematopoiesis (specifically, B lymphopoiesis), pancreatic beta cell and whit
Last changed: 2014-11-21 19:49:01

Reaction: PDX1-dependent synthesis of NKX6-1 protein (Homo sapiens)
In mature beta-cells of the pancreas, the NKX6-1 gene is transcribed, its mRNA is translated, and the protein product is transported to the nucleus. NKX6-1 transcription is positively regulated by the activity of the PDX1 transcription factor. These events and interactions have not been studied directly in humans, but are inferred from corresponding ones worked out in the mouse
Last changed: 2014-11-21 06:36:34

Reaction: PDX1-dependent synthesis of IAPP protein (Homo sapiens)
The IAPP gene, encoding islet amyloid precursor protein, is transcribed and its mRNA is translated. IAPP transcription is positively regulated by PDX1 transcription factor. These events and interactions are inferred from corresponding ones studied in molecular detail in the mouse
Last changed: 2014-11-21 06:36:34

Reaction: PDX1-dependent synthesis of NR5A2 protein (Homo sapiens)
The NR5A2 gene is transcribed, its mRNA is translated, and the protein product is transported to the ... NR5A2 transcription requires the activity of the PDX1 transcription factor. These events and interactions have not been studied in vivo in humans, but are inferred from corresponding ones worked out in the mouse and from in vitro studies of PDX1 protein binding to the Nr5A2 gene (Annicotte et al. 2 ...
Last changed: 2014-11-21 14:40:22

Reaction: PDX1-dependent synthesis of NKX6-1 protein (Homo sapiens)
The NKX6-1 gene is transcribed, its mRNA is translated, and the protein product is transported to the nucleus. NKX6-1 transcription requires the activity of the PDX1 transcription factor. These events and interactions have not been studied directly in humans, but are inferred from corresponding ones worked out in the mouse
Last changed: 2014-11-21 06:36:34

Reaction: NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein (Homo sapiens)
The glucokinase (GCK) gene is transcribed and its mRNA is translated. GCK transcription is positively regulated by the activity of the NEUROD1 and PDX1 transcription factors. These events and interactions are inferred from corresponding ones studied in molecular detail in the mouse
Last changed: 2014-11-21 19:49:01

Reaction: HNF6- and FGF10-dependent synthesis of PDX1 protein (Homo sapiens)
The PDX1 gene is transcribed, its mRNA is translated, and the protein product is transported to the nucleus. PDX1 transcription requires the activities of the HNF6 transcription factor and FGF10. These events and interactions have not been studied directly in humans, but are inferred from corresponding ones worked out in the mouse
Last changed: 2014-11-21 06:36:34

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