Reactome: A Curated Pathway Database

Interleukin-6 binds to soluble IL-6 receptor (R-HSA-1067640)

Species Homo sapiens


The short, soluble form of Interleukin-6 receptor alpha (sIL6R), like the longer membrane-associated form IL6RA, binds circulating Interleukin-6 (IL-6). sIL6R is generated by limited proteolysis of the longer membrane associated form and by translation of an alternatively spliced mRNA. The IL-6:sIL6R dimer can associate with the IL6 receptor signaling beta subunit gp130 and stimulate cells that do not express IL6RA, a process termed trans-signaling. Gp130 is widely expressed in many cell types that do not express IL6RA (Rose-John et al. 2006).

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Additional Information
Compartment extracellular region
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Cross References
Database Identifier
IntAct EBI-9007455, EBI-9007450, EBI-9007446, EBI-9007422, EBI-1036752|rcsb, pdb:1P9M
Literature References
pubMedId Title Journal Year
2788034 Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130 Cell 1989