Reactome: A Curated Pathway Database
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Interleukin-6 binds to soluble IL-6 receptor

Stable Identifier
R-HSA-1067640
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The short, soluble form of Interleukin-6 receptor alpha (sIL6R), like the longer membrane-associated form IL6RA, binds circulating Interleukin-6 (IL-6). sIL6R is generated by limited proteolysis of the longer membrane associated form and by translation of an alternatively spliced mRNA. The IL-6:sIL6R dimer can associate with the IL6 receptor signaling beta subunit gp130 and stimulate cells that do not express IL6RA, a process termed trans-signaling. Gp130 is widely expressed in many cell types that do not express IL6RA (Rose-John et al. 2006).

Literature References
Participants
Participant Of
Orthologous Events