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IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)

Stable Identifier
R-HSA-1067651
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
IL6:sIL6R binds to JAKs:IL6RB (gp130)
Locations in the PathwayBrowser
Summation

The complex of interleukin-6 (IL6) and the soluble, short form of the IL6 receptor (IL6R-2) binds to surface expressed IL6ST (gp130), a process known as trans signaling (Rose-John et al. 2006). This process is negatively regulated by the soluble form of IL6ST (IL6ST-2).

Participants
Participant Of
This entity is regulated by
Orthologous Events