Reactome: A Curated Pathway Database

IL6:IL6R-2 binds IL6ST-2

Stable Identifier
R-HSA-1067676
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
IL6:sIL6R binds sgp130
Locations in the PathwayBrowser
Summation

Soluble IL6ST (sgp130) binds to circulating Interleukin-6 (IL6) bound to the soluble form of IL6 receptor alpha (IL6:IL6R-2), preventing binding to IL6ST (gp130) on the plasma membrane, thereby specifically inhibiting IL6 trans-signaling (Jostock et al. 2001).

Literature References
Participants
Participant Of
Orthologous Events
Cross References