Reactome: A Curated Pathway Database

IL6:sIL6R binds sgp130 (R-HSA-1067676)

Species Homo sapiens


Soluble gp130 binds to circulating IL6:sIL6R, preventing binding to gp130 on the plasma membrane, thereby specifically inhibiting IL-6 trans-signaling (Jostock et al. 2001). This protein is to enter clinical development for the treatment of inflammatory diseases. It can be anticipated that less beneficial activities of IL-6 will be blocked by soluble gp130 than by global blockade of IL-6 with neutralizing monoclonal antibodies to IL-6 or IL-6R

Locations in the PathwayBrowser
Additional Information
Compartment extracellular region
Components of this entry
Input entries
Output entries
Cross References
Database Identifier
IntAct EBI-9007450, EBI-9007441, EBI-1036752|rcsb, pdb:1P9M
Literature References
pubMedId Title Journal Year
11121117 Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses Eur J Biochem 2001