Reactome: A Curated Pathway Database

IL6:sIL6R binds sgp130 (R-HSA-1067676) [Homo sapiens]

Reaction
Summation

Soluble gp130 binds to circulating IL6:sIL6R, preventing binding to gp130 on the plasma membrane, thereby specifically inhibiting IL-6 trans-signaling (Jostock et al. 2001). This protein is to enter clinical development for the treatment of inflammatory diseases. It can be anticipated that less beneficial activities of IL-6 will be blocked by soluble gp130 than by global blockade of IL-6 with neutralizing monoclonal antibodies to IL-6 or IL-6R

Additional Information
Compartment extracellular region
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Literature References
pubMedId Title Journal Year
11121117 Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses Eur J Biochem 2001