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IL6:IL6R-2 [extracellular region]
Stable Identifier
R-HSA-1067687
Type
Complex
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-6 family signaling (Homo sapiens)
Interleukin-6 signaling (Homo sapiens)
Assembly of hexameric IL-6 receptor (Homo sapiens)
IL6 receptor hexamer:JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 receptor trimer:JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 binds IL6R-2 (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6:IL6R-2 binds IL6ST-2 (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6:IL6R-2:IL6ST-2 [extracellular region] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6:IL6R-2:IL6ST-2 [extracellular region] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6ST is tyrosine phosphorylated (Homo sapiens)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
JAK activation (Homo sapiens)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
IL6 receptor hexamer:JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
PTPN11 binds CBL (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
PTPN11 binds p-Y759-IL6ST (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
PTPN11 is phosphorylated (Homo sapiens)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
Phosphorylated STATs are released (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
SOCS3 binds IL6ST (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
Serine phosphorylation of STATs (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine/serine phosphorylated STAT1/3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF-independent MAPK1/3 activation (Homo sapiens)
MAPK1 (ERK2) activation (Homo sapiens)
MAP2K2 binds MAPK1 (Homo sapiens)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
MAPK3 (ERK1) activation (Homo sapiens)
MAP2K1 binds MAPK3 (Homo sapiens)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R-2 [extracellular region] (Homo sapiens)
Participants
components
IL6 [extracellular region]
(Homo sapiens)
IL6R-2 [extracellular region]
(Homo sapiens)
Participates
as an input of
IL6:IL6R-2 binds IL6ST-2 (Homo sapiens)
IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (Homo sapiens)
as an output of
IL6 binds IL6R-2 (Homo sapiens)
as a component of
IL6:IL6R-2:IL6ST-2 [extracellular region] (Homo sapiens)
IL6:sIL6R:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane] (Homo sapiens)
Inferred To
IL6:IL6R-2 [extracellular region]
(Bos taurus)
IL6:IL6R-2 [extracellular region]
(Canis familiaris)
IL6:IL6R-2 [extracellular region]
(Danio rerio)
IL6:IL6R-2 [extracellular region]
(Gallus gallus)
IL6:IL6R-2 [extracellular region]
(Mus musculus)
IL6:IL6R-2 [extracellular region]
(Rattus norvegicus)
IL6:IL6R-2 [extracellular region]
(Sus scrofa)
IL6:IL6R-2 [extracellular region]
(Xenopus tropicalis)
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