Reactome: A Curated Pathway Database

IL6:IL6RA binds JAKs:IL6RB (gp130)

Stable Identifier
R-HSA-1067688
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The complex of IL-6 bound to the IL-6 receptor alpha subunit binds the IL-6 receptor beta subunit gp130. Site II of IL-6 within the binary complex interacts with the cytokine binding-homology region of gp130. Subsequently, site III of IL-6 interacts with the gp130 immunoglobulin-like activation domain.

Literature References
Participants
Participant Of
Orthologous Events