Reactome: A Curated Pathway Database

IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)

Stable Identifier
R-HSA-1067688
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
IL6:IL6R binds IL6ST:JAKs
Locations in the PathwayBrowser
Summation

The complex of interleukin-6 (IL6) bound to the IL6 receptor alpha subunit (IL6R) binds the IL-6 receptor beta subunit IL6ST (gp130), which constitutively binds JAK kinases. Site II of IL6 interacts with the cytokine binding-homology region of IL6ST. Subsequently, site III of IL6 interacts with the IL6ST immunoglobulin-like activation domain.

Literature References
Participants
Participant Of
Orthologous Events