Reactome: A Curated Pathway Database

IL6:IL6RA binds JAKs:IL6RB (gp130) (R-HSA-1067688)

Species Homo sapiens


The complex of IL-6 bound to the IL-6 receptor alpha subunit binds the IL-6 receptor beta subunit gp130. Site II of IL-6 within the binary complex interacts with the cytokine binding-homology region of gp130. Subsequently, site III of IL-6 interacts with the gp130 immunoglobulin-like activation domain.

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Compartment plasma membrane
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Literature References
pubMedId Title Journal Year
2788034 Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130 Cell 1989