There will be a maintenance on OICR IT systems starting Friday Dec 15 at 6PM EST until midnight Sunday Dec 17; Reactome will be affected by this downtime

Service under maintenance from Friday Dec 15 at 6PM EST until midnight Sunday Dec 17

Formation of the closed pre-initiation complex

Stable Identifier
R-HSA-109639
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The binding of TFIIH completes the assembly of the preinitiation complex (PIC) for RNA Polymerase II transcription. Although RNA polymerase binds the TATA box on the promoter DNA, no initiation of transcription occurs until TFIIH is bound to the PIC. TFIIH is the only factor with known enzymatic activities.

Literature References
PubMed ID Title Journal Year
8946909 The general transcription factors of RNA polymerase II. Genes Dev 1997
Participants
Participant Of
Orthologous Events