Formation of the closed pre-initiation complex

Stable Identifier
R-HSA-109639
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Formation of the closed pre-initiation complex
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The binding of TFIIH completes the assembly of the preinitiation complex (PIC) for RNA Polymerase II transcription. Although RNA polymerase binds the TATA box on the promoter DNA, no initiation of transcription occurs until TFIIH is bound to the PIC. TFIIH is the only factor with known enzymatic activities.
Literature References
PubMed ID Title Journal Year
8946909 The general transcription factors of RNA polymerase II.

Orphanides, G, Reinberg, D, Lagrange, T

Genes Dev 1997
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Authored
Reinberg, D  (2003-09-11)
Created
Reinberg, D  (2003-09-11)
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