Reactome: A Curated Pathway Database

Formation of the closed pre-initiation complex (R-HSA-109639) [Homo sapiens]


The binding of TFIIH completes the assembly of the preinitiation complex (PIC) for RNA Polymerase II transcription. Although RNA polymerase binds the TATA box on the promoter DNA, no initiation of transcription occurs until TFIIH is bound to the PIC. TFIIH is the only factor with known enzymatic activities.

Additional Information
Compartment nucleoplasm
Literature References
pubMedId Title Journal Year
8946909 The general transcription factors of RNA polymerase II. Genes Dev 1997