Reactome: A Curated Pathway Database

Formation of the closed pre-initiation complex

Stable Identifier
R-HSA-109639
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The binding of TFIIH completes the assembly of the preinitiation complex (PIC) for RNA Polymerase II transcription. Although RNA polymerase binds the TATA box on the promoter DNA, no initiation of transcription occurs until TFIIH is bound to the PIC. TFIIH is the only factor with known enzymatic activities.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events