PDPK1 phosphorylates AKT2 (R-HSA-109702) [Homo sapiens]


Two specific sites in AKT2, one in the kinase domain (Thr-309) and the other in the C-terminal regulatory region (Ser-474), need to be phosphorylated for its full activation.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol , plasma membrane
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
PDPK1:PIP3 protein serine/threonine kinase activity (0004674)  
Literature References
pubMedId Title Journal Year
9094314 Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha Curr Biol 1997
9228007 Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B Science 1997
15890450 Activation of a GST-tagged AKT2/PKBbeta Biochim. Biophys. Acta 2005
Inferred Entries
Orthologous events