Reactome: A Curated Pathway Database
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PDPK1 phosphorylates AKT2

Stable Identifier
R-HSA-109702
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Phosphorylation of PKB by PDK1
Locations in the PathwayBrowser
Summation

Two specific sites in AKT2, one in the kinase domain (Thr-309) and the other in the C-terminal regulatory region (Ser-474), need to be phosphorylated for its full activation.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of PDPK1:PIP3 [plasma membrane] PDPK1:PIP3 [plasma membrane] protein serine/threonine kinase activity (0004674)
Orthologous Events