PDPK1 phosphorylates AKT2

Stable Identifier
R-HSA-109702
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Phosphorylation of PKB by PDK1
Locations in the PathwayBrowser
Summation

Two specific sites in AKT2, one in the kinase domain (Thr-309) and the other in the C-terminal regulatory region (Ser-474), need to be phosphorylated for its full activation.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of PDPK1:PIP3 [plasma membrane]
Physical Entity
Activity
Orthologous Events