Reactome: A Curated Pathway Database

PKB-mediated events

Stable Identifier
R-HSA-109703
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

PKB and PDK1 are activated via membrane-bound PIP3. Activated PDK1 phosphorylates PKB, which in turn phosphorylates PDE3B. The latter hydrolyses cAMP to 5'AMP, depleting cAMP pools.

Participants
Participant Of
hasEvent
Orthologous Events