Reactome: A Curated Pathway Database

p-S259,S621-RAF1

Stable Identifier
R-HSA-109786
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
RAF proto-oncogene serine/threonine-protein kinase , Raf-1, C-RAF, cRaf
Locations in the PathwayBrowser
External Reference Information
External Reference
Gene Names
RAF1, RAF
Chain
chain:1-648
Reference Genes
Reference Transcript
Other Identifiers
 11716472_a_at  11748273_a_at  16950848  1917_at  1C1Y
 1FAQ  1FAR  1GUA  1RFA  201244_s_at
 2663243  2663245  2663246  2663247  2663248
 2663251  2663253  2663258  2663261  2663263
 2663270  2663271  2663272  2663273  2663274
 2663275  2663278  2663279  2663280  2663281
 2663282  2663283  2663284  2663292  38742_s_at
 38743_f_at  3CU8  3IQJ  3IQU  3IQV
 3KUC  3KUD  3NKX  3O8I  3OMV
 4FJ3  4G0N  4G3X  4IEA  4IHL
 5894  8085374  A0A0S2Z559  A_23_P40952  AAA60247
 AAH18119  AAP03432  ABY87557  AGC09606  AK312248
 ALQ33755  ALQ33756  AY271661  BAG35180  BC018119
 CAA27204  CAB019291  CCDS2612  cg00496504  cg02830576
 cg12173506  cg15011209  cg18331396  CH471055  EAW64134
 EAW64135  ENSG00000132155  ENSP00000251849  ENSP00000401888  ENST00000251849
 ENST00000442415  EntrezGene:5894  EU332868  g4506400_3p_a_at  HGNC:9829
 HPA002640  ILMN_1813489  IPR000719  IPR001245  IPR002219
 IPR003116  IPR008271  IPR011009  IPR017441  IPR020454
 IPR029071  JX512459  KU178297  KU178298  L00206
 L00207  L00208  L00209  L00210  L00211
 L00212  L00213  L7RRS6  LRG_413  LRG_413t1
 M11376  MIM:164760  MIM:611553  MIM:611554  MIM:615916
 NM_002880  NP_002871  PF00130  PF02196  PF07714
 PH_hs_0039978  PR00008  RAF1  RAF1-001  RAF1-007
 SM00109  SM00220  SM00455  TC03001174.hg  uc003bxf.5
 uc062gvt.1  UPI0000049CFC  UPI000178DE79  X03484  X03484_at
 X54851  XM_005265355  XM_005265357  XM_005265358  XM_011533974
 XM_011533975  XP_005265412  XP_005265414  XP_005265415  XP_011532276
 XP_011532277
Participant Of
Other forms of this molecule
Inferred To
Modified Residues
Name Coordinate Modification PsiMod
O-phospho-L-serine at 259 259
O-phospho-L-serine [MOD:00046] A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
O-phospho-L-serine at 621 621
O-phospho-L-serine [MOD:00046] A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
UCSC human
ZINC_target
GeneCards
DOCK Blaster
PRO
HMDB_protein
Protein Data Bank
Interactors
Confidence Score Interactor Accession Interactor Name Evidence (IntAct)
0.957 P01112 RASH_HUMAN 17
0.954 P63104 1433Z_HUMAN 16
0.928 P31946 1433B_HUMAN 18
0.88 Q02750 MP2K1_HUMAN 31
0.878 P15056 BRAF_HUMAN 46
0.773 Q04917 1433F_HUMAN 6
0.744 P27348 1433T_HUMAN 4
0.708 Q16543 CDC37_HUMAN 4
0.688 P08238 HS90B_HUMAN 3
0.688 P04049 RAF1_HUMAN 4
0.669 P31947 1433S_HUMAN 3
0.669 P61981 1433G_HUMAN 3
0.667 P36507 MP2K2_HUMAN 3
0.664 P30086 PEBP1_HUMAN 7
0.659 P62258 1433E_HUMAN 3
0.643 Q13418 ILK_HUMAN 3
0.623 P62834 RAP1A_HUMAN 2
0.597 Q96S96 PEBP4_HUMAN 4
0.589 P31749 AKT1_HUMAN 2
0.589 Q92934 BAD_HUMAN 2
0.576 P11021 GRP78_HUMAN 4
0.558 Q13177 PAK2_HUMAN 2
0.556 O39474 O39474_9HEPC 4
0.547 Q3ZCQ8 TIM50_HUMAN 4
0.544 P01116-2 KRAS 2
0.527 O43852 CALU_HUMAN 2
0.508 Q99933 BAG1_HUMAN 2
0.508 P03495 NS1_I72A2 2
0.499 Q9ESN9-2 MAPK8IP3 2
0.499 P01120 RAS2_YEAST 2
0.499 P28301 LYOX_MOUSE 2
0.488 P05783 K1C18_HUMAN 5
0.456 P67775 PP2AA_HUMAN 2
0.456 Q13362 2A5G_HUMAN 2