Reactome: A Curated Pathway Database

p-S259,S621-RAF1 (R-HSA-109786) [Homo sapiens]

Reference Gene Product
Locations in the PathwayBrowser
Additional Information
External reference name RAF1
External reference id P04049
Synonyms RAF proto-oncogene serine/threonine-protein kinase , Raf-1, C-RAF
Compartment cytosol
Other Identifiers
 11716472_a_at  11748273_a_at  1917_at  1C1Y  1FAQ
 1FAR  1GUA  1RFA  201244_s_at  38742_s_at
 38743_f_at  3CU8  3IQJ  3IQU  3IQV
 3KUC  3KUD  3NKX  3O8I  3OMV
 4FJ3  4G0N  4G3X  4IEA  4IHL
 5894  A_23_P40952  AAA60247  AAH18119  AAP03432
 ABY87557  AGC09606  AK312248  AY271661  BAG35180
 BC018119  CAA27204  CAB019291  CCDS2612  CH471055
 EAW64134  EAW64135  ENSG00000132155  ENSP00000251849  ENSP00000401888
 ENST00000251849  ENST00000442415  EntrezGene:5894  EU332868  g4506400_3p_a_at
 HGNC:9829  HPA002640  ILMN_1813489  IPR000719  IPR001245
 IPR002219  IPR002290  IPR003116  IPR008271  IPR011009
 IPR017441  IPR020454  IPR029071  JX512459  L00206
 L00207  L00208  L00209  L00210  L00211
 L00212  L00213  L7RRS6  LRG_413  LRG_413t1
 M11376  MIM:164760  NM_002880  NP_002871  OTTHUMP00000160218
 OTTHUMP00000207813  PF00130  PF02196  PF07714  PH_hs_0039978
 PR00008  R-HSA-109582  R-HSA-112314  R-HSA-112315  R-HSA-112316
 R-HSA-112399  R-HSA-112412  R-HSA-1227986  R-HSA-1236394  R-HSA-1250196
 R-HSA-1250347  R-HSA-1266738  R-HSA-1280215  R-HSA-1280218  R-HSA-1433557
 R-HSA-162582  R-HSA-166520  R-HSA-167044  R-HSA-168249  R-HSA-168256
 R-HSA-169893  R-HSA-170968  R-HSA-170984  R-HSA-177929  R-HSA-179812
 R-HSA-180336  R-HSA-186763  R-HSA-186797  R-HSA-187037  R-HSA-187687
 R-HSA-187706  R-HSA-190236  R-HSA-194138  R-HSA-1963640  R-HSA-2172127
 R-HSA-2404192  R-HSA-2424491  R-HSA-2428924  R-HSA-2428928  R-HSA-2454202
 R-HSA-2586552  R-HSA-2672351  R-HSA-2871796  R-HSA-372790  R-HSA-375165
 R-HSA-382551  R-HSA-392517  R-HSA-422475  R-HSA-430116  R-HSA-438064
 R-HSA-4420097  R-HSA-442742  R-HSA-442755  R-HSA-449147  R-HSA-451927
 R-HSA-512988  R-HSA-5218921  R-HSA-5621481  R-HSA-5621575  R-HSA-5654687
 R-HSA-5654693  R-HSA-5654696  R-HSA-5654700  R-HSA-5654706  R-HSA-5654708
 R-HSA-5654712  R-HSA-5654716  R-HSA-5654736  R-HSA-5654738  R-HSA-5654741
 R-HSA-5654743  R-HSA-5673000  R-HSA-5673001  R-HSA-5674135  R-HSA-5674499
 R-HSA-5675221  R-HSA-5683057  R-HSA-5684996  R-HSA-74751  R-HSA-74752
 R-HSA-76002  R-HSA-881907  R-HSA-912526  R-HSA-983712  RAF1
 RAF1-001  RAF1-007  SM00109  SM00220  SM00455
 uc003bxf.5  uc062gvt.1  UPI0000049CFC  UPI000178DE79  X03484
 X03484_at  X54851  XM_005265355  XM_005265357  XM_005265358
 XM_011533974  XM_011533975  XP_005265412  XP_005265414  XP_005265415
 XP_011532276  XP_011532277
Secondary Identifiers RAF1_HUMAN, B0LPH8, B2R5N3, Q15278, Q9UC20
Gene Names RAF1, RAF
Chain chain:1-648
This entry is a component of:
hasMember
Reference Genes
Database Identifier
dbSNP Gene 5894
CTD Gene 5894
BioGPS Gene 5894
NCBI Gene 5894
ENSEMBL ENSG00000132155
KEGG Gene RAF1
Orphanet 16828
Reference Transcripts
Database Identifier
RefSeq NM_002880
Cross References
Database Identifier
RefSeq NP_002871
ZINC_target P04049
DOCK Blaster 4G0N, 4G3X, 3KUC, 3KUD, 3OMV, 1FAR, 1GUA, 1RFA, 1C1Y, 1FAQ, 4IHL, 4FJ3, 3CU8, 3NKX, 4IEA, 3O8I, 3IQV, 3IQJ, 3IQU
HMDB_protein HMDBP01153
PRO P04049
GeneCards P04049
UCSC human P04049
Protein Data Bank 4G0N, 4G3X, 3KUC, 3KUD, 3OMV, 1FAR, 1GUA, 1RFA, 1C1Y, 1FAQ, 4IHL, 4FJ3, 3CU8, 3NKX, 4IEA, 3O8I, 3IQV, 3IQJ, 3IQU
ModifiedResidues
Name Coordinate Modification PsiMod Name PsiMod Identifier PsiMod Definition
O-phospho-L-serine at 259 259 O-phospho-L-serine 00046 A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
O-phospho-L-serine at 621 621 O-phospho-L-serine 00046 A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Inferred Entries
Inferred to
Interactions
Confidence Score Interactor Accession Interactor Name Evidences
0.957 P01112 RASH 17
0.954 P63104 1433Z 16
0.928 P31946 1433B 18
0.88 Q02750 MP2K1 31
0.878 P15056 BRAF 46
0.773 Q04917 1433F 6
0.744 P27348 1433T 4
0.708 Q16543 CDC37 4
0.688 P08238 HS90B 3
0.688 P04049 RAF1 4
0.669 P61981 1433G 3
0.669 P31947 1433S 3
0.667 P36507 MP2K2 3
0.664 P30086 PEBP1 7
0.659 P62258 1433E 3
0.643 Q13418 ILK 3
0.623 P62834 RAP1A 2
0.597 Q96S96 PEBP4 4
0.589 P31749 AKT1 2
0.589 Q92934 BAD 2
0.576 P11021 GRP78 4
0.558 Q13177 PAK2 2
0.556 O39474 O39474 9HEPC 4
0.547 Q3ZCQ8 TIM50 4
0.544 P01116-2 KRAS 2
0.527 O43852 CALU 2
0.508 Q99933 BAG1 2
0.508 P03495 NS1 I72A2 2
0.499 P01120 RAS2 YEAST 2
0.499 P28301 LYOX MOUSE 2
0.499 Q9ESN9-2 MAPK8IP3 2
0.488 P05783 K1C18 5
0.456 P67775 PP2AA 2
0.456 Q13362 2A5G 2