Reactome: A Curated Pathway Database

p-S259,S621-RAF1 (R-HSA-109786)

Species Homo sapiens

Locations in the PathwayBrowser
Developmental Biology(Homo sapiens)
Immune System(Homo sapiens)

Signal Transduction(Homo sapiens)

Other forms of this molecule

Additional Information
External reference name RAF1
External reference id P04049
Synonyms RAF proto-oncogene serine/threonine-protein kinase , Raf-1, C-RAF
Compartment cytosol
Other Identifiers 11716472_a_at, 11748273_a_at, 1917_at, 1C1Y, 1FAQ, 1FAR, 1GUA, 1RFA, 201244_s_at, 38742_s_at, 38743_f_at, 3CU8, 3IQJ, 3IQU, 3IQV, 3KUC, 3KUD, 3NKX, 3O8I, 3OMV, 4FJ3, 4G0N, 4G3X, 4IEA, 4IHL, 5894, A_23_P40952, AAA60247, AAH18119, AAP03432, ABY87557, AGC09606, AK312248, AY271661, BAG35180, BC018119, CAA27204, CAB019291, CCDS2612, CH471055, EAW64134, EAW64135, ENSG00000132155, ENSP00000251849, ENSP00000401888, ENST00000251849, ENST00000442415, EntrezGene:5894, EU332868, g4506400_3p_a_at, HGNC:9829, HPA002640, ILMN_1813489, IPR000719, IPR001245, IPR002219, IPR002290, IPR003116, IPR008271, IPR011009, IPR017441, IPR020454, IPR029071, JX512459, L00206, L00207, L00208, L00209, L00210, L00211, L00212, L00213, L7RRS6, LRG_413, LRG_413t1, M11376, MIM:164760, MIM:611553, MIM:611554, MIM:615916, NM_002880, NP_002871, OTTHUMP00000160218, OTTHUMP00000207813, PF00130, PF02196, PF07714, PH_hs_0039978, PR00008, R-HSA-109582, R-HSA-112314, R-HSA-112315, R-HSA-112316, R-HSA-112399, R-HSA-112412, R-HSA-1227986, R-HSA-1236394, R-HSA-1250196, R-HSA-1250347, R-HSA-1266738, R-HSA-1280215, R-HSA-1280218, R-HSA-1433557, R-HSA-162582, R-HSA-166520, R-HSA-167044, R-HSA-168249, R-HSA-168256, R-HSA-169893, R-HSA-170968, R-HSA-170984, R-HSA-177929, R-HSA-179812, R-HSA-180336, R-HSA-186763, R-HSA-186797, R-HSA-187037, R-HSA-187687, R-HSA-187706, R-HSA-190236, R-HSA-194138, R-HSA-1963640, R-HSA-2172127, R-HSA-2404192, R-HSA-2424491, R-HSA-2428924, R-HSA-2428928, R-HSA-2454202, R-HSA-2586552, R-HSA-2672351, R-HSA-2871796, R-HSA-372790, R-HSA-375165, R-HSA-382551, R-HSA-392517, R-HSA-422475, R-HSA-430116, R-HSA-438064, R-HSA-4420097, R-HSA-442742, R-HSA-442755, R-HSA-449147, R-HSA-451927, R-HSA-512988, R-HSA-5218921, R-HSA-5621481, R-HSA-5621575, R-HSA-5654687, R-HSA-5654693, R-HSA-5654696, R-HSA-5654700, R-HSA-5654706, R-HSA-5654708, R-HSA-5654712, R-HSA-5654716, R-HSA-5654736, R-HSA-5654738, R-HSA-5654741, R-HSA-5654743, R-HSA-5673000, R-HSA-5673001, R-HSA-5674135, R-HSA-5674499, R-HSA-5675221, R-HSA-5683057, R-HSA-5684996, R-HSA-74751, R-HSA-74752, R-HSA-76002, R-HSA-881907, R-HSA-912526, R-HSA-983712, RAF1, RAF1-001, RAF1-007, SM00109, SM00220, SM00455, uc003bxf.5, uc062gvt.1, UPI0000049CFC, UPI000178DE79, X03484, X03484_at, X54851, XM_005265355, XM_011533974, XP_005265412, XP_011532276
Secondary Identifiers RAF1_HUMAN, B0LPH8, B2R5N3, Q15278, Q9UC20
Gene Names RAF1, RAF
Chain chain:1-648
This entry is a component of:
hasMember
Reference Genes
Database Identifier
dbSNP Gene 5894
CTD Gene 5894
BioGPS Gene 5894
NCBI Gene 5894
ENSEMBL ENSG00000132155
KEGG Gene 5894
Orphanet 16828
Reference Transcripts
Database Identifier
RefSeq NM_002880
Cross References
Database Identifier
RefSeq NP_002871
ZINC_target P04049
DOCK Blaster 3OMV, 4G0N, 4G3X, 1RFA, 3KUC, 3KUD, 1FAR, 1GUA, 1C1Y, 1FAQ, 3CU8, 3NKX, 4FJ3, 4IHL, 4IEA, 3O8I, 3IQV, 3IQJ, 3IQU
HMDB_protein HMDBP01153
PRO P04049
GeneCards P04049
UCSC human P04049
Protein Data Bank 3OMV, 4G0N, 4G3X, 1RFA, 3KUC, 3KUD, 1FAR, 1GUA, 1C1Y, 1FAQ, 3CU8, 3NKX, 4FJ3, 4IHL, 4IEA, 3O8I, 3IQV, 3IQJ, 3IQU
ModifiedResidues
Name Coordinate Modification PsiMod Name PsiMod Identifier PsiMod Definition
O-phospho-L-serine at 259 259 O-phospho-L-serine 00046 A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
O-phospho-L-serine at 621 621 O-phospho-L-serine 00046 A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Inferred Entries
Inferred to