Reactome: A Curated Pathway Database

MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (R-HSA-109822) [Homo sapiens]

Reaction
Summation

At the beginning of this reaction, 1 molecule of 'ATP', and 1 molecule of 'GRB2:SOS:SHC-P' are present. At the end of this reaction, 1 molecule of 'GRB2:SHC-P', 1 molecule of 'phospho-SOS', and 1 molecule of 'ADP' are present.

Additional Information
Compartment cytosol
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
MAPK3,(MAPK1) kinase activity (0016301)  
Literature References
pubMedId Title Journal Year
7739560 Insulin-stimulated disassociation of the SOS-Grb2 complex. Mol Cell Biol 1995