Reactome: A Curated Pathway Database

MAP2K1 phosphorylates MAPK3 (R-HSA-109860) [Homo sapiens]


MAP2K1 (also known as MEK1) phosphorylates the critical Thr202 and Tyr204 on MAPK3 (ERK1), converting two ATP to ADP. Phosphorylation of MAPK3 activates its kinase activity.

MAP2K1 activation requires the phosphorylation of two serine residues (S218 and S222) in the activation loop.

Additional Information
Compartment cytosol
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Input entries
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Catalyst Activity
PhysicalEntity Activity Active Units
p-2S-MAP2K1:MAPK3 protein serine/threonine kinase activity (0004674)
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Regulation type Name