Reactome: A Curated Pathway Database

MAP2K1 phosphorylates MAPK3

Stable Identifier
R-HSA-109860
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

MAP2K1 (also known as MEK1) phosphorylates the critical Thr202 and Tyr204 on MAPK3 (ERK1), converting two ATP to ADP. Phosphorylation of MAPK3 activates its kinase activity.

MAP2K1 activation requires the phosphorylation of two serine residues (S218 and S222) in the activation loop.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of p-2S-MAP2K1:MAPK3 [cytosol] p-2S-MAP2K1:MAPK3 [cytosol] protein serine/threonine kinase activity (0004674)
Orthologous Events