Reactome: A Curated Pathway Database

Global Genomic NER (GG-NER) (R-HSA-109970)

Species Homo sapiens

Summation

GG-NER is considered to be transcription-independent, removing lesions from non-transcribed regions of genome in addition to non-transcribed strands of transcribed regions.
The three events that characterize NER are well characterized in GG-NER: damage recognition, bimodal incision of DNA via repair protein complex, resulting excision of DNA fragment with the lesion. Post-excision polymerization and ligation restore back the native chemistry and configuration to the damaged DNA.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm