Reactome: A Curated Pathway Database

Assembly of repair proteins at the site of Pol II blockage (R-HSA-109973)

Species Homo sapiens


A proper assembly of repair complex may require displacement of Pol II from the damage site exposing a significant length of the corresponding template DNA with the lesions. Speculations on the mode of this displacement of Pol II are available from experimental evidences: a. CSB mediated dissociation of Pol II b. degradation of Pol II c. CSB mediated remodeling of damaged DNA-RNA PII interface etc.
The TC-repair complex now consists of damaged DNA template: nascent mRNA hybrid. The damage site needs to be exposed to subsequent endonuclease activities.

Locations in the PathwayBrowser
Additional Information
Compartment nucleoplasm