Reactome: A Curated Pathway Database

POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template

Stable Identifier
R-HSA-110316
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Binding of Pol eta to lesioned DNA template
Locations in the PathwayBrowser
Summation

DNA polymerase eta (POLH) belongs to Y family of DNA polymerases. POLH binds PCNA monoubiquitinated at lysine K164 by the RAD18:UBE2B (RAD18:RAD6) or RBX1:CUL4:DDB1:DTL complexes in response to DNA damage. POLH C-terminus contains a conserved PCNA interaction motif, while the catalytic domain of POLH contains a conserved monoubiquitin binding motif. POLH is most efficient in recognition and repair of thymine-thymine cyclobutane pyrimidine dimers (TT-CPD) induced by UV-mediated DNA damage (Masutani et al. 2000, Kannouche et al. 2004)

Literature References
Participants
Participant Of
Orthologous Events