Reactome: A Curated Pathway Database

Elongation by POLH

Stable Identifier
R-HSA-110319
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

After incorporating two dAMPs opposite the thymine-thymine cyclobutane pyrimidine dimer (TT-CPD), DNA polymerase eta (POLH) can continue translesion DNA synthesis (TLS). POLH preferentially incorporates dAMPs and dGMPs, and may introduce one error per every 18-380 nucleotides (dNMPs) added. POLH stalls after incorporation of a mispaired dNMP, which limits POLH- mediated mutagenesis, in addition to the subsequent polymerase switch (Matsuda et al. 2000, Masutani et al. 2000).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
DNA-directed DNA polymerase activity of POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA)-DNA Template [nucleoplasm] POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA)-DNA Template [nucleoplasm] DNA-directed DNA polymerase activity (0003887)
Orthologous Events