Reactome: A Curated Pathway Database

Elongation by POLH (R-HSA-110319) [Homo sapiens]


After incorporating two dAMPs opposite the thymine-thymine cyclobutane pyrimidine dimer (TT-CPD), DNA polymerase eta (POLH) can continue translesion DNA synthesis (TLS). POLH preferentially incorporates dAMPs and dGMPs, and may introduce one error per every 18-380 nucleotides (dNMPs) added. POLH stalls after incorporation of a mispaired dNMP, which limits POLH- mediated mutagenesis, in addition to the subsequent polymerase switch (Matsuda et al. 2000, Masutani et al. 2000).

Additional Information
Compartment nucleoplasm
Literature References
pubMedId Title Journal Year
10801132 Low fidelity DNA synthesis by human DNA polymerase-eta Nature 2000
10856253 Mechanisms of accurate translesion synthesis by human DNA polymerase eta. EMBO J 2000