Reactome: A Curated Pathway Database

Translesion Synthesis by POLH

Stable Identifier
R-HSA-110320
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

DNA polymerase eta (POLH) consists of 713 amino acids and can bypass thymidine-thymidine dimers, correctly adding two dAMPs opposite to the lesion. Mutations in the POLH gene result in the loss of this bypass activity and account for the XP variant phenotype (XPV) in human xeroderma pigmentosum disorder patients. POLH can carry out TLS past various UV and chemically induced lesions via two steps: (a) preferential incorporation of correct bases opposite to the lesion (b) conditional elongation only at the sites where such correct bases are inserted (Masutani et al. 1999, Masutani et al. 2000).

Literature References
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database