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Cleavage of the damaged pyrimidine
Stable Identifier
R-HSA-110329
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Base-Excision Repair, AP Site Formation (Homo sapiens)
Depyrimidination (Homo sapiens)
Cleavage of the damaged pyrimidine (Homo sapiens)
General
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Damaged pyrimidines are cleaved by pyrimide-specific glycosylases (Lindahl and Wood 1999).
Literature References
PubMed ID
Title
Journal
Year
10583946
Quality control by DNA repair
Lindahl, T
,
Wood, RD
Science
1999
Participants
Events
Cleavage of uracil by UNG glycosylase
(Homo sapiens)
Cleavage of 5-hydroxyluracil by UNG glycosylase
(Homo sapiens)
Cleavage of uracil by TDG glycosylase
(Homo sapiens)
Cleavage of thymine by TDG glycosylase
(Homo sapiens)
Cleavage of uracil by SMUG1 glycosylase
(Homo sapiens)
Cleavage of thymine glycol by NTHL1 glycosylase
(Homo sapiens)
Cleavage of cytosine glycol by NTHL1 glycosylase
(Homo sapiens)
Cleavage of dihydrouracil by NTHL1 glycosylase
(Homo sapiens)
Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase
(Homo sapiens)
Cleavage of uracil by MBD4 glycosylase
(Homo sapiens)
Cleavage of thymine by MBD4 glycosylase
(Homo sapiens)
Cleavage of ethenocytosine by TDG glycosylase
(Homo sapiens)
Excision of FapyG by OGG1 glycosylase
(Homo sapiens)
NEIL1 cleaves DHU from damaged DNA
(Homo sapiens)
NEIL1 cleaves FapyA from damaged DNA
(Homo sapiens)
NEIL1 cleaves FapyG from damaged DNA
(Homo sapiens)
NEIL1 cleaves thymine glycol from damaged DNA
(Homo sapiens)
NEIL2 cleaves 5-OHU from damaged DNA
(Homo sapiens)
NEIL3 cleaves thymine glycol from telomeric DNA
(Homo sapiens)
NEIL3 cleaves thymine glycol
(Homo sapiens)
Participates
as an event of
Depyrimidination (Homo sapiens)
Event Information
Go Biological Process
depyrimidination (0045008)
Orthologous Events
Cleavage of the damaged pyrimidine (Bos taurus)
Cleavage of the damaged pyrimidine (Caenorhabditis elegans)
Cleavage of the damaged pyrimidine (Canis familiaris)
Cleavage of the damaged pyrimidine (Danio rerio)
Cleavage of the damaged pyrimidine (Dictyostelium discoideum)
Cleavage of the damaged pyrimidine (Drosophila melanogaster)
Cleavage of the damaged pyrimidine (Gallus gallus)
Cleavage of the damaged pyrimidine (Mus musculus)
Cleavage of the damaged pyrimidine (Plasmodium falciparum)
Cleavage of the damaged pyrimidine (Rattus norvegicus)
Cleavage of the damaged pyrimidine (Saccharomyces cerevisiae)
Cleavage of the damaged pyrimidine (Schizosaccharomyces pombe)
Cleavage of the damaged pyrimidine (Sus scrofa)
Cleavage of the damaged pyrimidine (Xenopus tropicalis)
Authored
Matthews, L (2004-02-03)
Reviewed
Borowiec, JA (2014-12-22)
Created
Matthews, L (2004-01-29)
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