Reactome: A Curated Pathway Database

D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (R-HSA-111215)

Species Homo sapiens

Summation

Cytosolic phosphoribosyl pyrophosphate synthetase 1 catalyzes the reaction of D-ribose 5-phosphate and dATP to form 5-phospho-alpha-D-ribose 1-diphosphate and 2'-deoxyadenosine 5'-monophosphate. While phosphoribosyl pyrophosphate synthetase 1 works well with either ATP or dATP as a substrate in vitro, the extent of the dATP reaction in vivo is unclear, as cellular dATP concentrations are normally very low (Fox and Kelley 1971).

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Additional Information
Compartment cytosol
Components of this entry
Input entries
Output entries
Literature References
pubMedId Title Journal Year
4328836 Human phosphoribosylpyrophosphate synthetase J Biol Chem 1971
Inferred Entries
Orthologous events