Reactome: A Curated Pathway Database

D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (R-HSA-111215) [Homo sapiens]


Cytosolic phosphoribosyl pyrophosphate synthetase 1 catalyzes the reaction of D-ribose 5-phosphate and dATP to form 5-phospho-alpha-D-ribose 1-diphosphate and 2'-deoxyadenosine 5'-monophosphate. While phosphoribosyl pyrophosphate synthetase 1 works well with either ATP or dATP as a substrate in vitro, the extent of the dATP reaction in vivo is unclear, as cellular dATP concentrations are normally very low (Fox and Kelley 1971).

Additional Information
Compartment cytosol
Components of this entry
Input entries
Output entries
Literature References
pubMedId Title Journal Year
4328836 Human phosphoribosylpyrophosphate synthetase J Biol Chem 1971
Inferred Entries
Orthologous events