Reactome: A Curated Pathway Database
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Phosphorylation of gp130

Stable Identifier
R-HSA-1112510
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Activated JAKs are believed to be responsible for phosphorylating the cytoplasmic region of gp130 (Wang & Fuller 1994, Reich & Liu 2006) creating docking sites for adaptor and downstream signaling molecules, in particular the STAT factors STAT1 and STAT3. Several phosphotyrosine residues of gp130 are docking sites for STAT factors (Stahl et al. 1995, Gerhartz et al. 1996), Tyr-759 phosphorylation allows recruitment of the phosphatase SHP2.

Literature References
Participants
Participant Of
Orthologous Events