Activated JAKs are believed to be responsible for phosphorylating the cytoplasmic region of gp130 (Wang & Fuller 1994, Reich & Liu 2006) creating docking sites for adaptor and downstream signaling molecules, in particular the STAT factors STAT1 and STAT3. Several phosphotyrosine residues of gp130 are docking sites for STAT factors (Stahl et al. 1995, Gerhartz et al. 1996), Tyr-759 phosphorylation allows recruitment of the phosphatase SHP2.
|7812050||Phosphorylation and internalization of gp130 occur after IL-6 activation of Jak2 kinase in hepatocytes||Mol Biol Cell||1994|
|16868551||Tracking STAT nuclear traffic||Nat Rev Immunol||2006|