Reactome: A Curated Pathway Database

Tyrosine phosphorylated IL6ST binds STAT1,STAT3

Stable Identifier
R-HSA-1112565
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
STATs bind gp130 phosphotyrosines
Locations in the PathwayBrowser
Summation

STAT1 binds to IL6ST (gp130) via phosphotyrosine residues 905 and 915 within two YXPD recognition motifs. STAT3 can be recruited to these sites and to two additional sites around Y767 and Y814 that have less restricted sequence recognition requirements (YXXQ) (Gerhartz et al. 1996). After receptor binding, STATs are phosphorylated on a single tyrosine residue by JAKs (Hemmann et al. 1996).

Literature References
Participants
Participant Of
Orthologous Events