Reactome: A Curated Pathway Database
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STATs bind gp130 phosphotyrosines

Stable Identifier
R-HSA-1112565
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

STAT1 binds to gp130 via phosphotyrosine residues 905 and 915, these located within two YXPD recognition motifs. STAT3 can also be recruited to these sites as well as two additional sites around Y767 and Y814, these having less restricted sequence recognition requirements (YXXQ) (Gerhartz et al. 1996). Subsequent to receptor binding, these STAT factors are phosphorylated on a single tyrosine residue by JAKs (Hemmann et al. 1996).

Literature References
Participants
Participant Of
Orthologous Events