Reactome: A Curated Pathway Database

Tyrosine phosphorylation of STATs by IL6 receptor (R-HSA-1112602)

Species Homo sapiens

Summation

IL-6 activates the tyrosine phosphorylation of STATs (Akira et al. 1994, Zhong et al. 1994) by JAKs (Hemmann et al. 1996) at a site that is essential for dimerization. For STAT1 this is tyrosine-701, for STAT3 tyrosine-705 (Kaptein et al. 1996, Shuai et al. 1994). Tyrosine phosphorylation leads to homo- or heterodimerization and translocation to the nucleus (Zhong et al. 1994), where the dimers bind to enhancers of interleukin-6- inducible genes e.g. acute phase protein genes, resulting in transcriptional activation.

Locations in the PathwayBrowser
Additional Information
Compartment plasma membrane , cytosol
This entry is regulated by
Regulation type Name
NegativeRegulation