Reactome: A Curated Pathway Database

Tyrosine phosphorylation of STATs by IL6 receptor

Stable Identifier
R-HSA-1112602
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

IL-6 activates the tyrosine phosphorylation of STATs (Akira et al. 1994, Zhong et al. 1994) by JAKs (Hemmann et al. 1996) at a site that is essential for dimerization. For STAT1 this is tyrosine-701, for STAT3 tyrosine-705 (Kaptein et al. 1996, Shuai et al. 1994). Tyrosine phosphorylation leads to homo- or heterodimerization and translocation to the nucleus (Zhong et al. 1994), where the dimers bind to enhancers of interleukin-6- inducible genes e.g. acute phase protein genes, resulting in transcriptional activation.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
non-membrane spanning protein tyrosine kinase activity of Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1/3 [plasma membrane] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1/3 [plasma membrane] non-membrane spanning protein tyrosine kinase activity (0004715)
Orthologous Events