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Serine phosphorylation of STATs
Stable Identifier
R-HSA-1112727
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-6 family signaling (Homo sapiens)
Interleukin-6 signaling (Homo sapiens)
Serine phosphorylation of STATs (Homo sapiens)
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In addition to tyrosine phosphorylation, STAT1 and STAT3 are phosphorylated at serine-727, which contributes to maximal transcriptional activity (Wen & Darnell 1997, Shen et al. 2004). Though several candidates exist, including Protein kinase C delta (Jain et al. 1999), the kinase responsible for Interleukin-6 regulation of STAT serine phosphorylation is unknown (Jain et al. 1999, Abe et al. 2001, Chung et al. 1997) and the significance of serine phosphorylation is unclear (Decker & Kovarik 2000). STAT3 modifed by serine phosphorylation augments oxidative phosphorylation in mitochondria and supported cellular transformation by oncogenic Ras (Reich 2009).
Literature References
PubMed ID
Title
Journal
Year
10851062
Serine phosphorylation of STATs
Kovarik, P
,
Decker, T
Oncogene
2000
Participants
Input
x 2
ATP [cytosol]
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane]
(Homo sapiens)
Output
x 2
ADP [cytosol]
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine/serine phosphorylated STAT1/3 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Interleukin-6 signaling (Homo sapiens)
Orthologous Events
Serine phosphorylation of STATs (Bos taurus)
Serine phosphorylation of STATs (Canis familiaris)
Serine phosphorylation of STATs (Danio rerio)
Serine phosphorylation of STATs (Gallus gallus)
Serine phosphorylation of STATs (Mus musculus)
Serine phosphorylation of STATs (Rattus norvegicus)
Serine phosphorylation of STATs (Sus scrofa)
Serine phosphorylation of STATs (Xenopus tropicalis)
Authored
Ray, KP (2010-12-13)
Reviewed
Rose-John, S (2011-02-11)
Created
Jupe, S (2010-12-10)
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