Activation of BIM and translocation to mitochondria

Stable Identifier
R-HSA-111446
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

BIM acts as a sentinel to check the integrity of the cytoskeleton. It exists as two variant proteins: BIM-EL and BIM-L. In healthy cells, these two isoforms are sequestered to the dynein motor complex on microtubules via the dynein light chain DLC1. JNK or MAPK8 releases BIM in response to UV irradiation by phosphorylation.

Literature References
PubMed ID Title Journal Year
14764673 B cell receptor-mediated apoptosis of human lymphocytes is associated with a new regulatory pathway of Bim isoform expression.

Mouhamad, S, Besnault, L, Auffredou, MT, Leprince, C, Bourgeade, MF, Leca, G, Vazquez, A

J Immunol 2004
Participants
Participant Of
Event Information
Orthologous Events
Authored
Reviewed