The switching on/off of its phosphorylation by growth/survival factors regulates BAD activity. BAD remains sequestered by 14-3-3 scaffold proteins after phosphorylation by Akt1. Calcineurin activates BAD by dephosphorylation.
|GO Biological Process||positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway (1900740)|
|15231831||BAD Is a Pro-survival Factor Prior to Activation of Its Pro-apoptotic Function.||J Biol Chem||2004|