Activation of BAD and translocation to mitochondria

Stable Identifier
R-HSA-111447
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The switching on/off of its phosphorylation by growth/survival factors regulates BAD activity. BAD remains sequestered by 14-3-3 scaffold proteins after phosphorylation by Akt1. Calcineurin activates BAD by dephosphorylation.

Literature References
PubMed ID Title Journal Year
15231831 BAD Is a Pro-survival Factor Prior to Activation of Its Pro-apoptotic Function. J Biol Chem 2004
Participants
Participant Of
Event Information
Orthologous Events