NOXA is transactivated in a p53-dependent manner and by E2F1. Activated NOXA is translocated to mitochondria.
|GO Biological Process||positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway (1900740)|
|15126337||Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53||Cancer Res||2004|
|14684737||Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis||J Biol Chem||2004|