Reactome: A Curated Pathway Database

Activation and oligomerization of BAK protein (R-HSA-111452)

Species Homo sapiens

Summation

tBID binds to its mitochondrial partner BAK to release cytochrome c. Activated tBID results in an allosteric activation of BAK. This may induce its intramembranous oligomerization into a pore for cytochrome c efflux.

Locations in the PathwayBrowser
Cross References
Database Identifier
BioModels Database BIOMD0000000220