Reactome: A Curated Pathway Database

Activation and oligomerization of BAK protein (R-HSA-111452)

Species Homo sapiens


tBID binds to its mitochondrial partner BAK to release cytochrome c. Activated tBID results in an allosteric activation of BAK. This may induce its intramembranous oligomerization into a pore for cytochrome c efflux.

Locations in the PathwayBrowser
Cross References
Database Identifier
BioModels Database BIOMD0000000220