Reactome: A Curated Pathway Database
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Activation and oligomerization of BAK protein

Stable Identifier
R-HSA-111452
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

tBID binds to its mitochondrial partner BAK to release cytochrome c. Activated tBID results in an allosteric activation of BAK. This may induce its intramembranous oligomerization into a pore for cytochrome c efflux.

Participants
Participant Of
Orthologous Events
Cross References