BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

Stable Identifier
R-HSA-111453
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Bcl-2 interacts with tBid (Yi et al. 2003), BIM (Puthalakath et al. 1999), PUMA (Nakano and Vousden 2001), NOXA (Oda et al. 2000), BAD (Yang et al. 2005), BMF (Puthalakath et al. 2001), resulting in inactivation of BCL2. Binding of BCL2 to tBID inhibits BID-induced cytochrome C release and apoptosis (Yi et al. 2003). BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL.

Participants
Participant Of
Event Information
Orthologous Events
Cross References
BioModels Database