Reactome: A Curated Pathway Database

Release of apoptotic factors from the mitochondria

Stable Identifier
R-HSA-111457
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Apoptotic factors released from the mitochondria promote apoptosis through several different mechanisms. Cytochrome C participates in Apoptosome driven effector caspase activation while SMAC relieves IAP mediated caspase inhibition.

Literature References
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database