Reactome: A Curated Pathway Database
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SMAC-mediated dissociation of IAP:caspase complexes

Stable Identifier
R-HSA-111464
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Smac/DIABLO regulates IAP function. Residues 56-59 of Smac/DIABLO are homologous to the amino-terminal motif that is used by caspase-9 to bind to the BIR3 domain of XIAP. Binding of Smac/DIABLO to XIAP thus displaces caspase-9 from the XIAP:Caspase complex (reviewed in Salvesen et al., 2002).

Literature References
PubMed ID Title Journal Year
12042762 IAP proteins: blocking the road to death's door Nat Rev Mol Cell Biol 2002
Participants
Participant Of
Orthologous Events
Cross References