Reactome: A Curated Pathway Database

Apoptotic cleavage of cellular proteins (R-HSA-111465)

Species Homo sapiens


Apoptotic cell death is achieved by the caspase-mediated cleavage of various vital proteins. Among caspase targets are proteins such as E-cadherin, Beta-catenin, alpha fodrin, GAS2, FADK, alpha adducin, HIP-55, and desmoglein involved in cell adhesion and maintenance of the cytoskeletal architecture. Cleavage of proteins such as APC and CIAP1 can further stimulate apoptosis by produce proapoptotic proteins (reviewed in Fischer et al., 2003. See also Wee et al., 2006 and the CASVM Caspase Substrates Database: ).

Locations in the PathwayBrowser
Additional Information
Compartment cytosol
Cross References
Database Identifier
BioModels Database BIOMD0000000243, BIOMD0000000407, BIOMD0000000220
Literature References
pubMedId Title Journal Year
12655297 Many cuts to ruin: a comprehensive update of caspase substrates Cell Death Differ 2003
17254298 SVM-based prediction of caspase substrate cleavage sites BMC Bioinformatics 2006
17599937 CASVM: web server for SVM-based prediction of caspase substrates cleavage sites Bioinformatics 2007